- ►nottingham.ac.uk [PDF] AP Russell, J Feilchenfeldt, S Schreiber, M … - Diabetes, 2003 - Am Diabetes Assoc The peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PGC-1)
can induce mitochondria biogenesis and has been implicated in the development of
oxidative type I muscle fibers. The PPAR isoforms α, β/δ, and γ control ... Cited by 136 - Related articles - BL Direct - All 6 versions
- ►physiology.org CK Roberts, RJ Barnard - Journal of Applied Physiology, 2005 - Am Physiological Soc Currently, modern chronic diseases, including cardiovascular diseases, Type 2
diabetes, metabolic syndrome, and cancer, are the leading killers in Westernized
society and are increasing rampantly in developing nations. In fact, ... Cited by 123 - Related articles - All 11 versions
- ►nih.gov C Ling, P Poulsen, E Carlsson, M … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Genetic and environmental factors contribute to age-dependent susceptibility to
type 2 diabetes. Recent studies have reported reduced expression of PPARγ
coactivator 1α (PGC-1α) and PGC-1β genes in skeletal muscle from type 2 ... Cited by 111 - Related articles - BL Direct - All 9 versions
- ►pnas.org KR Short, ML Bigelow, J Kahl, R Singh, J … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are
reported to accelerate aging in mice. We determined whether aging results in
increased DNA oxidative damage and reduced mtDNA abundance and ... Cited by 109 - Related articles - All 11 versions
- ►adisonline.com [PDF] S Carroll, M Dudfield - Sports Medicine, 2004 - ingentaconnect.com Prevention of the metabolic syndrome and treatment of its main characteristics
Abstract are now considered of utmost importance in order to combat the epidemic
of type 2 diabetes mellitus and to reduce the increased risk of ... Cited by 109 - Related articles - BL Direct - All 8 versions
AE Civitarese, S Carling, LK Heilbronn, MH … - PLoS medicine, 2007 - pubmedcentral.nih.gov The current study was undertaken to examine muscle mitochondrial bioenergetics
in response to caloric restriction alone or in combination with exercise in 36
young (36.8 ± 1.0 y), overweight (body mass index, 27.8 ± 0.7 kg/m 2 ) ... Cited by 97 - Related articles - All 7 versions
- ►nih.gov R Boushel, E Gnaiger, P Schjerling, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Insulin resistance and type 2 diabetes are associated
with mitochondrial dysfunction. The aim of the present study was to test the
hypothesis that oxidative phosphorylation and electron transport capacity ... Cited by 79 - Related articles - BL Direct - All 9 versions
- ►ajcn.org KS Nair - American Journal of Clinical Nutrition, 2005 - Am Soc Nutrition Age causes structural and functional changes in skeletal muscle in a wide range
of species, including humans. Muscle changes in humans start in the fourth
decade of life and cause frailty and disabilities. Associated changes in ... Cited by 70 - Related articles - All 9 versions
- ►nih.gov R Cartoni, B Leger, MB Hock, M Praz, A … - The Journal of Physiology, 2005 - Physiological Soc Mitochondrial impairment is hypothesized to contribute to the pathogenesis of
insulin resistance. Mitofusin (Mfn) proteins regulate the biogenesis and
maintenance of the mitochondrial network, and when inactivated, cause a ... Cited by 63 - Related articles - BL Direct - All 9 versions
- ►physiology.org L DiPietro, J Dziura, CW Yeckel, PD Neufer - Journal of Applied Physiology, 2006 - Am Physiological Soc Few studies have compared the relative benefits of moderate- vs. higher
intensity exercise training on improving insulin sensitivity in older people
while holding exercise volume constant. Healthy older (73 ± 10 yr) women ... Cited by 62 - Related articles - BL Direct - All 7 versions
