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Scholar Results 1 - 10 of about 49 citing Wilkes: Chronic endothelin-1 treatment leads to insulin resistance in vivo. (0.11 sec) 

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin …

- nih.gov
H Satoh, MTA Nguyen, PDG Miles, T … - Journal of Clinical …, 2004 - Am Soc Clin Investig
We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism
by overexpressing resistin protein in male Wistar rats using intravenous administration of an
adenovirus encoding mouse resistin. After 7 days of elevated resistin levels at a ...
Cited by 159 - Related articles - BL Direct - All 7 versions

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation


P Gual, Y Le Marchand-Brustel, JF Tanti - Biochimie, 2005 - Elsevier
This review will provide insight on the current understanding of the regulation of insulin signaling
in both physiological and pathological conditions through modulations that occur with regards
to the functions of the insulin receptor substrate 1 (IRS1). While the phosphorylation of ...
Cited by 159 - Related articles - All 3 versions

Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in …


F Dong, X Zhang, LE Wold, Q Ren, Z … - British journal of …, 2005 - pubmedcentral.nih.gov
Endothelin-1 (ET-1), an endothelium-derived vasoactive peptide, participates in the regulation
of endothelial function through mechanisms that are not fully elucidated. This study examined
the impact of ET-1 on oxidative stress, apoptosis and cell proliferation in human umbilical ...
Cited by 62 - Related articles - All 8 versions

Regulation of adiponectin secretion by endothelin-1


KJ Clarke, Q Zhong, DD Schwartz, ES Coleman, RJ … - … and Biophysical Research …, 2003 - Elsevier
Adiponectin is an adipocyte-derived hormone best known for its insulin-sensitizing ability. The
expression and circulating concentration of adiponectin are decreased in type 2 diabetics and
increase following treatment with thiazolidinediones. Endothelin-1 (ET-1) is a potent ...
Cited by 42 - Related articles - All 5 versions

Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in …

- physiology.org
LD Monti, E Setola, G Fragasso, RP … - American Journal of …, 2006 - Am Physiological Soc
The aim of the present study was to evaluate the effect of prolonged inhibition of -oxidation on
glucose and lipid muscle forearm metabolism and cGMP and endothelin-1 forearm release in
patients with type 2 diabetes mellitus and ischemic cardiomyopathy. Fifteen patients were ...
Cited by 41 - Related articles - BL Direct - All 5 versions

Insulin and endothelin: an interplay contributing to hypertension development?

- endojournals.org
PA Sarafidis, GL Bakris - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc
Evidence Synthesis: Several mechanisms connect insulin resistance and compensatory hyperinsulinemia
with blood pressure elevation in the context of the metabolic syndrome, ie sodium retention, sympathetic
activation, and impairment of endothelial nitric oxide production. Accumulating evidence ...
Cited by 28 - Related articles - BL Direct - All 6 versions

Phosphatidylinositol 4, 5-Bisphosphate Reverses Endothelin-1–Induced Insulin …

- diabetesjournals.org
AB Strawbridge, JS Elmendorf - Diabetes, 2005 - Am Diabetes Assoc
Phosphatidylinositol (PI) 4,5-bisphosphate (PIP 2 ) plays a pivotal role in insulin-stimulated glucose
transport as an important precursor to PI 3,4,5-trisphosphate (PIP 3 ) and a key regulator of actin
polymerization. Since endothelin (ET)-1 impairs insulin sensitivity and PIP 2 is a target of ...
Cited by 26 - Related articles - All 6 versions

Topiramate is an insulin-sensitizing compound in vivo with direct effects on …

- physiology.org
JJ Wilkes, E Nelson, M Osborne, KT … - American Journal of …, 2005 - Am Physiological Soc
We have studied the in vivo and in vitro effects of Topiramate (TPM) in female Zucker diabetic
fatty (ZDF) rats. After weight matching, drug treatment had a marked effect to lower fasting glucose
levels of relatively normoglycemic animals as well as during an oral glucose tolerance ...
Cited by 24 - Related articles - All 4 versions

Haplotypes in the urotensin II gene and urotensin II receptor gene are associated …


KL Ong, LYF Wong, YB Man, RYH Leung, YQ Song, … - Peptides, 2006 - Elsevier
We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II
(UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and
306 normotensive unrelated subjects) and their relation to hypertension and the ...
Cited by 23 - Related articles - All 5 versions

Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric …

- physiology.org
P Lucotti, E Setola, LD Monti, E Galluccio, … - American Journal of …, 2006 - Am Physiological Soc
Because chronic L-arginine supplementation improves insulin sensitivity and endothelial function
in nonobese type 2 diabetic patients, the aim of this study was to evaluate the effects of a
long-term oral L-arginine therapy on adipose fat mass (FM) and muscle free-fat mass ...
Cited by 22 - Related articles - BL Direct - All 4 versions


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