HF Kramer, CA Witczak, N Fujii, N Jessen, EB Taylor, … - Diabetes, 2006 - Am Diabetes Assoc Insulin and contraction increase GLUT4 translocation in skeletal muscle via distinct signaling
mechanisms. Akt substrate of 160 kDa (AS160) mediates insulin-stimulated GLUT4 translocation
in L6 myotubes, presumably through activation of Akt. Using in vivo, in vitro, and in situ ... Cited by 85 - Related articles - BL Direct - All 6 versions
YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB Kahn - Diabetes, 2003 - Am Diabetes Assoc In humans with obesity or type 2 diabetes, insulin target tissues are resistant to many actions
of insulin. The atypical protein kinase C (PKC) isoforms λ and ζ are downstream of
phosphatidylinositol-3 kinase (PI3K) and are required for maximal insulin stimulation of ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM Olefsky - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance is predominantly characterized by decreased insulin-stimulated glucose uptake
into skeletal muscle. In the current study, we have assessed various aspects of the phosphatidylinositol
(PI) 3-kinase pathway in skeletal muscle biopsies obtained from normal, obese ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►physiology.org AJ Rose, EA Richter - Physiology, 2005 - Am Physiological Soc During dynamic exercise, the turnover of ATP in skeletal muscle increases greatly and is fuelled
by the catabolism of carbohydrates (intramuscular glycogen, blood glucose) and fatty acids
(intramuscular triglycerides, blood lipids). During exercise in the postabsorptive state, the ... Cited by 60 - Related articles - BL Direct - All 4 versions
JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI Shulman … - Journal of Biological …, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►oxfordjournals.org M Desrois, RJ Sidell, D Gauguier, … - Cardiovascular …, 2004 - cardiovascres.oxfordjournals.org Objective: Whole body insulin resistance and diabetes are risk factors for cardiovascular
diseases, yet little is known about insulin resistance in the diabetic heart. The aim of this work
was to define the insulin response in hearts of the Goto–Kakizaki (GK) rat, a polygenic ... Cited by 51 - Related articles - All 8 versions
A Zorzano, M Palacin, A Guma… - Acta Physiologica …, 2005 - interscience.wiley.com Skeletal muscle is a major glucose-utilizing tissue in the absorptive state and the major glucose
transporter expressed in muscle in adulthood is GLUT4. GLUT4 expression is exquisitely regulated
in muscle and this seems important in the regulation of insulin-stimulated glucose uptake ... Cited by 43 - Related articles - All 4 versions
- ►uidaho.edu [PDF] A KROOK, H WALLBERG-HENRIKSSON, JR … - Medicine & Science in …, 2004 - journals.lww.com KROOK, A., H. WALLBERG-HENRIKSSON, and JR ZIERATH. Sending the Signal: Molecular
Mechanisms Regulating Glucose Uptake. Med. Sci. Sports Exerc., Vol. 36, No. 7, pp.
1212-1217, 2004. The molecular signaling mechanisms by which insulin leads to ... Cited by 39 - Related articles - BL Direct - All 8 versions
G Sesti - Best Practice & Research Clinical Endocrinology & …, 2006 - Elsevier Insulin resistance is a feature of a number of clinical disorders, including type 2 diabetes/glucose
intolerance, obesity, dyslipidaemia and hypertension clustering in the so-called metabolic
syndrome. Insulin resistance in skeletal muscle manifests itself primarily as a reduction in ... Cited by 39 - Related articles - All 9 versions
S Perrini, J Henriksson, JR Zierath, U Widegren - Diabetes, 2004 - Am Diabetes Assoc We determined whether protein kinase C (PKC) isoforms are redistributed and phosphorylated
in response to acute exercise in skeletal muscle. Muscle biopsies were obtained from six healthy
subjects (four women, two men; age 25 ± 1 years) before, during, and after 60 min of ... Cited by 37 - Related articles - BL Direct - All 4 versions
