MT Nguyen, H Satoh, S Favelyukis, JL Babendure, … - Journal of Biological …, 2005 - ASBMB Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin
resistance. In this study, we treated 3T3-L1 adipocytes with a mixture of free fatty acids
(FFAs) to investigate the molecular mechanisms underlying fat-induced insulin ... Cited by 150 - Related articles - BL Direct - All 6 versions
M Beeson, MP Sajan, M Dizon, D Grebenev, J Gomez- … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance in type 2 diabetes is partly due to impaired glucose transport in skeletal
muscle. Atypical protein kinase C (aPKC) and protein kinase B (PKB), operating downstream
of phosphatidylinositol (PI) 3-kinase and its lipid product, PI-3,4,5-(PO 4 ) 3 (PIP 3 ), ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM Olefsky - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance is predominantly characterized by decreased insulin-stimulated glucose uptake
into skeletal muscle. In the current study, we have assessed various aspects of the phosphatidylinositol
(PI) 3-kinase pathway in skeletal muscle biopsies obtained from normal, obese ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►physiology.org DS Fernandez-Twinn, A Wayman, S … - American Journal of …, 2005 - Am Physiological Soc Human adult diseases such as cardiovascular disease, hypertension, and type 2 diabetes have
been epidemiologically linked to poor fetal growth and development. Male offspring of rat dams
fed a low-protein (LP) diet during pregnancy and lactation develop diabetes with ... Cited by 66 - Related articles - All 4 versions
- ►sciencesignaling.org Y Zick - Science's STKE, 2005 - stke.sciencemag.org The duration and extent of signals induced by insulin, our major anabolic hormone, are tightly
regulated to promote proper metabolism, energy balance, and maintenance of normal body
weight. Impaired ability to generate these signals, termed insulin resistance, results in the ... Cited by 64 - Related articles - All 6 versions
- ►nih.gov WK Oh, L Abu-Elheiga, P Kordari, Z Gu, T … - Proceedings of the …, 2005 - National Acad Sciences Acc2 -/- mutant mice, when fed a high-fat/high-carbohydrate (HF/HC) diet, were protected against
diet-induced obesity and diabetes. To investigate the role of acetyl-CoA carboxylase 2
(ACC2) in the regulation of energy metabolism in adipose tissues, we studied fatty acid ... Cited by 62 - Related articles - All 11 versions
JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI Shulman … - Journal of Biological …, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►ebmonline.org RV Farese, MP Sajan, ML Standaert - Experimental Biology and Medicine, 2005 - SEBM Glucose transport into muscle is the initial process in glucose clearance and is uniformly defective
in insulin-resistant conditions of obesity, metabolic syndrome, and Type II diabetes mellitus. Insulin
regulates glucose transport by activating insulin receptor substrate-1 (IRS-1)–dependent ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org M Desrois, RJ Sidell, D Gauguier, … - Cardiovascular …, 2004 - cardiovascres.oxfordjournals.org Objective: Whole body insulin resistance and diabetes are risk factors for cardiovascular
diseases, yet little is known about insulin resistance in the diabetic heart. The aim of this work
was to define the insulin response in hearts of the Goto–Kakizaki (GK) rat, a polygenic ... Cited by 51 - Related articles - All 8 versions
- ►uidaho.edu [PDF] A KROOK, H WALLBERG-HENRIKSSON, JR … - Medicine & Science in …, 2004 - journals.lww.com KROOK, A., H. WALLBERG-HENRIKSSON, and JR ZIERATH. Sending the Signal: Molecular
Mechanisms Regulating Glucose Uptake. Med. Sci. Sports Exerc., Vol. 36, No. 7, pp.
1212-1217, 2004. The molecular signaling mechanisms by which insulin leads to ... Cited by 39 - Related articles - BL Direct - All 8 versions
