- ►rockefeller.edu [PDF] SF Leibowitz, KE Wortley - Peptides, 2004 - Elsevier Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades, major
advances have been made in identifying an increasing number of peptides within the ... Cited by 104 - Related articles - All 7 versions
- ►ufl.edu [PDF] KH Warrington, RW Herzog - Human genetics, 2006 - Springer Abstract During the past decade, in vivo administration of viral gene transfer vectors for treatment
of numerous human diseases has been brought from bench to bedside in the form of clinical
trials, mostly aimed at establishing the safety of the protocol. In preclinical studies in ... Cited by 68 - Related articles - BL Direct - All 4 versions
Y Zhang, PJ Scarpace - Physiology & behavior, 2006 - Elsevier Although the presence of hyperleptinemia with leptin resistance and obesity has long been
recognized, a causal role of elevated leptin in these biological states remains unclear. This article
summarizes some recent work from our laboratory supporting the concept that leptin, in ... Cited by 52 - Related articles - All 3 versions
C Asensio, P Muzzin, F Rohner-Jeanrenaud - International journal of obesity, 2004 - nature.com Glucocorticoids are important hormones in the regulation of metabolic homeostasis. We infused
normal rats with dexamethasone given intracerebroventricularly (icv) for 3 days. This resulted
in hyperphagia, hyperinsulinemia, and marked insulin resistance. Similar metabolic ... Cited by 40 - Related articles - All 6 versions
- ►endocrinology-journals.org [PDF] G Li, Y Zhang, JT Wilsey, PJ Scarpace - Journal of Endocrinology, 2004 - Soc Endocrinology The effects of the chronic activation of the central melano- cortin (MC) system by melanotan II
(MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO)
Sprague–Dawley rats. Six-day central infusion of MTII (1nmol/day) reduced body weight ... Cited by 31 - Related articles - BL Direct - All 4 versions
HE Bays, JM Gonzlez-Campoy, GA Bray, AE … - Expert Review of …, 2008 - ingentaconnect.com When caloric intake exceeds caloric expenditure, the positive caloric balance and storage of
energy in adipose tissue often causes adipocyte hypertrophy and visceral adipose tissue
accumulation. These pathogenic anatomic abnormalities may incite metabolic and ... Cited by 27 - Related articles - All 4 versions
G Li, Y Zhang, JT Wilsey, PJ Scarpace - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Age-related obesity is asso- ciated with impaired hypothalamic
pro-opiomelanocortin (Pomc) gene expression. We assessed whether overproduc- tion of POMC
in the hypothalamus ameliorates age-related obesity in rats. Methods: Recombinant ... Cited by 22 - Related articles - BL Direct - All 4 versions
Y Zhang, PJ Scarpace - Peptides, 2006 - Elsevier We identified that leptin resistance in aged-obese rats has both peripheral and central
components. The central resistance is characterized by diminished hypothalamic leptin receptors
and impaired leptin signal transduction. We developed a new model of leptin-induced ... Cited by 18 - Related articles - All 4 versions
- ►endocrinology-journals.org H Shimizu, K Inoue, M Mori - Journal of Endocrinology, 2007 - Soc Endocrinology The brain hypothalamus coordinates extra-hypothalamic regions to maintain energy homeostasis
through the regulation of food intake and energy expenditure. A number of anorexigenic and
orexigenic molecules in the hypothalamic nuclei participate in the control of energy ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Voss-Andreae, JG Murphy, KLJ Ellacott, RC Stuart, … - Endocrinology, 2007 - Endocrine Soc The central melanocortin 4 receptor (MC4R) plays a critical role in energy homeostasis, although
little is known regarding its role in the regulation of adaptive thermogenesis of brown adipose
tissue (BAT). Here we show using retrograde transsynaptic tracing with attenuated ... Cited by 15 - Related articles - BL Direct - All 3 versions
