S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes: one would generate
-cells ex vivo that are suitable for transplantation, and the second would stimulate regeneration
of -cells in the pancreas. Studies of ex vivo expansion suggest that -cells have a potential ... Cited by 175 - Related articles - All 3 versions
- ►ucsd.edu [PDF] E Hao, B Tyrberg, P Itkin-Ansari, JR Lakey, I Geron, EZ … - Nature medicine, 2006 - medscape.com The nature and even existence of adult pancreatic endocrine stem or progenitor cells is a subject
of controversy in the field of beta-cell replacement for diabetes. One place to search for such
cells is in the nonendocrine fraction of cells that remain after islet isolation, which consist ... Cited by 103 - Related articles - BL Direct - All 11 versions
S Bonner-Weir, E Toschi, A Inada, P Reitz, SY … - Pediatric …, 2004 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 101 - Related articles - BL Direct - All 3 versions
- ►alphamedpress.org Y Shi, L Hou, F Tang, W Jiang, P Wang, M Ding, H … - Stem Cells, 2005 - AlphaMed Press Experimental induction of embryonic stem cells (ESCs) to become pancreatic ß cells can potentially
provide ample resource for cell transplantation therapy of type I diabetes mellitus. Most of the
previously reported induction strategies were long and complicated, and some required ... Cited by 96 - Related articles - All 6 versions
L Baeyens, S De Breuck, J Lardon, JK Mfopou, I … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Transplantation of insulin- producing beta cells from donors can cure
diabetes, but they are available in insufficient quantities. In this study, we investigated the possibility
of generating insulin- producing cells from adult rat exocrine cells cultured in the ... Cited by 93 - Related articles - All 6 versions
LB Chen, XB Jiang, L Yang… - World Journal of Gastroenterology, 2004 - wjgnet.com METHODS: Rat MSCs were isolated from Wistar rats and cultured. Passaged MSCs were induced
to differentiate into islet-like cells under following conditions: pre-induction with L-DMEM including
10 mmol/L nicotinamide+1 mmol/L b-mercaptoethanol+200 mL/L fetal calf serum (FSC) ... Cited by 91 - Related articles - Cached - BL Direct - All 12 versions
- ►endojournals.org WL Suarez-Pinzon, JRT Lakey, SJ Brand, A … - Journal of Clinical …, 2005 - Endocrine Soc Pancreatic islet transplantation is a viable treatment for type 1 diabetes, but is limited by human
donor tissue availability. The combination of epidermal growth factor (EGF) and gastrin induces
islet ß-cell neogenesis from pancreatic exocrine duct cells in rodents. In this study we ... Cited by 69 - Related articles - All 5 versions
A Lechner, AL Nolan, RA Blacken, JF Habener - Biochemical and Biophysical …, 2005 - Elsevier Cellular replacement therapy holds promise for the treatment of diabetes mellitus but donor tissue
is severely limited. Therefore, we investigated whether insulin-secreting cells could be differentiated
in vitro from a monolayer of cells expanded from human donor pancreatic islets. We ... Cited by 64 - Related articles - All 4 versions
KL Seeberger, JM Dufour, AMJ Shapiro, JRT … - Laboratory …, 2006 - nature.com Fibroblast-like cells emerging from cultured human pancreatic endocrine and exocrine tissue
have been reported. Although a thorough phenotypic characterization of these cells has not yet
been carried out, these cells have been hypothesized to be contaminating fibroblasts, ... Cited by 56 - Related articles - BL Direct - All 6 versions
L Ouziel-Yahalom, M Zalzman, L Anker-Kitai, S … - … and Biophysical Research …, 2006 - Elsevier Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet insulin-producing
β cells. Insulin administration does not prevent long-term complications of the disease, since
the optimal insulin dosage is difficult to adjust. Replacement of the damaged cells with ... Cited by 54 - Related articles - All 4 versions
