G Keller - Genes & development, 2005 - genesdev.cshlp.org The discovery of mouse embryonic stem (ES) cells >20 years ago represented a major advance
in biology and experimental medicine, as it enabled the routine manipulation of the mouse
genome. Along with the capacity to induce genetic modifications, ES cells provided the ... Cited by 373 - Related articles - BL Direct - All 12 versions
P Blyszczuk, J Czyz, G Kania, M Wagner, … - Proceedings of the …, 2003 - National Acad Sciences Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers including
endodermal cells that produce insulin in vitro. We show that constitutive expression of Pax4
(Pax4 + ), and to a lesser extent Pdx1 (Pdx1 + ), affects the differentiation of ES cells and ... Cited by 327 - Related articles - BL Direct - All 11 versions
- ►alphamedpress.org HT Ku, N Zhang, A Kubo, R O'Connor, M Mao, G Keller, … - Stem Cells, 2004 - AlphaMed Press A panel of genetic markers was used to assess the in vitro commitment of murine embryonic
stem (ES) cells toward the endoderm-derived pancreas and to distinguish insulin-expressing
cells of this lineage from other lineages such as neuron, liver, and yolk sac. There are two ... Cited by 197 - Related articles - All 7 versions
S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes: one would generate
-cells ex vivo that are suitable for transplantation, and the second would stimulate regeneration
of -cells in the pancreas. Studies of ex vivo expansion suggest that -cells have a potential ... Cited by 175 - Related articles - All 3 versions
M Hansson, A Tonning, U Frandsen, A Petri, J … - Diabetes, 2004 - Am Diabetes Assoc Several recent reports claim the generation of insulin-producing cells from embryonic stem cells
via the differentiation of progenitors that express nestin. Here, we investigate further the properties
of these insulin-containing cells. We find that although differentiated cells contain ... Cited by 139 - Related articles - BL Direct - All 4 versions
- ►neiltheise.com [PDF] MA Hussain, ND Theise - The Lancet, 2004 - Elsevier Curative therapy for diabetes mellitus mainly implies replacement of functional insulin-producing
pancreatic β cells, with pancreas or islet-cell transplants. However, shortage of donor organs
spurs research into alternative means of generating β cells from islet expansion, ... Cited by 83 - Related articles - All 8 versions
- ►diabetesjournals.org GKC Brolén, N Heins, J Edsbagge, H Semb - Diabetes, 2005 - Am Diabetes Assoc The recent success in restoring normoglycemia in type 1 diabetes by islet cell transplantation
indicates that cell replacement therapy of this severe disease is achievable. However, the severe
lack of donor islets has increased the demand for alternative sources of β-cells, such as ... Cited by 81 - Related articles - BL Direct - All 6 versions
JH Shim, SE Kim, DH Woo, SK Kim, CH Oh, R McKay, … - Diabetologia, 2007 - Springer Page 1. ARTICLE Directed differentiation of human embryonic stem cells towards
a pancreatic cell fate JH Shim & SE Kim & DH Woo & SK Kim & CH Oh & R. McKay
& JH Kim Received: 3 July 2006 /Accepted: 15 January 2007 ... Cited by 48 - Related articles - BL Direct - All 5 versions
