- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the mechanisms
leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, ... Cited by 174 - Related articles - BL Direct - All 10 versions
J Hjelmesaeth, S Sagedal, A Hartmann, H Rollag, T … - Diabetologia, 2004 - Springer Aims/hypothesis. The human cytomegalovirus (CMV) may increase the risk of diabetes
mellitus, but the lit- erature is scarce. The present study was designed to test the hypothesis that
asymptomatic CMV infection is associated with increased risk of new-onset diabetes after ... Cited by 48 - Related articles - BL Direct - All 5 versions
N van der Werf, FG Kroese, J Rozing, JL … - Diabetes/Metabolism … - interscience.wiley.com During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly, reaching
percentages of 3% annually worldwide. This increase suggests that besides genetical factors
environmental perturbations (including viral infections) are also involved in the ... Cited by 39 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org M Flodstrom-Tullberg, M Hultcrantz, A … - The Journal of …, 2005 - Am Assoc Immnol Coxsackievirus (CV) is an important human pathogen that has been linked to the development
of autoimmunity. An intact pancreatic cell IFN response is critical for islet cell survival and protection
from type 1 diabetes following CV infection. In this study, we show that IFNs trigger an ... Cited by 34 - Related articles - All 4 versions
MS Horwitz, A Ilic, C Fine, B Balasa, N Sarvetnick - Clinical Immunology, 2004 - Elsevier Epidemiological studies have associated coxsackie B virus (CBV) with the development of
insulin-dependent diabetes mellitus (IDDM) in humans. Infections of genetically susceptible mice
with CBV strain 4 (CB4) induce autoimmune diabetes. Herein, we demonstrate that in ... Cited by 20 - Related articles - All 3 versions
AM Barral, HE Thomas, EM Ling, R Darwiche, E … - Journal of Autoimmunity, 2006 - Elsevier CD8 + cytotoxic T lymphocytes (CTL) can rapidly kill β-cells and therefore contribute to the development
of type 1 diabetes (T1D). CTL-mediated β-cell killing can occur via perforin-mediated lysis,
Fas–Fas-L interaction, and the secretion of TNF-α or IFN-γ. The secretion of IFN-γ can ... Cited by 15 - Related articles - All 4 versions
H Al-Hello, B Davydova, T Smura, S … - Journal of medical …, 2005 - interscience.wiley.com Common enterovirus infections appear to initiate or facilitate the pathogenetic processes leading
to type 1 diabetes, and also sometimes precipitate the clinical disease. In experimental infection
of mice, coxsackieviruses have shown to have a strong affinity for the exocrine tissue, ... Cited by 12 - Related articles - All 3 versions
- ►fasebj.org MM Zanone, E Favaro, E Ferioli, GC Huang, NJ Klein, … - The FASEB Journal, 2007 - FASEB Enteroviruses, such as the coxsackievirus (CV) group, have been linked to the induction of inflammatory
and autoimmune diseases. Virus tropism and tissue access are modulated by endothelial
cells. To examine the susceptibility of microvascular endothelial cells (MECs) derived ... Cited by 12 - Related articles - BL Direct - All 4 versions
AM Newell - Primary Care: Clinics in Office Practice, 2004 - Elsevier Diabetes mellitus serves as a valuable model for exploring how emerging “genomic”
concepts, tools, and knowledge might be applied in clinical practice to target disease
prevention. With a few rare exceptions, most cases of diabetes are the manifestation of a ... Cited by 9 - Related articles - BL Direct - All 4 versions
NJ Hill, M Hultcrantz, N Sarvetnick, M … - European journal of …, 2007 - interscience.wiley.com Central and peripheral tolerance mechanisms were for a long time the only regulatory circuits
known in autoimmunity. It is now becoming clear that the target tissue itself may have the capacity
to control its own destiny. Here we review mechanisms by which the target tissue ... Cited by 6 - Related articles - BL Direct - All 4 versions
