BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United
States, it is the leading cause of blindness, end-stage renal disease, and
nontraumatic loss of limb, with associated health care costs estimated to ... Cited by 510 - Related articles - All 6 versions
SJ Yeaman - Biochemical Journal, 2004 - pubmedcentral.nih.gov Although described initially as an intracellular adipocyte-specific
triacylglycerol lipase, it is now clear that HSL (hormone-sensitive lipase) is
expressed in multiple tissues and plays a number of roles in lipid ... Cited by 99 - Related articles - BL Direct - All 8 versions
- Free from Publisher F Ovalle, DSH Bell - Diabetes care, 2004 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A total of 17 subjects with type 2 diabetes,
inadequately controlled on a maximized oral antihyperglycemic double regimen of
glimepiride and metformin, were randomized to the addition of rosiglitazone ... Cited by 63 - Related articles - BL Direct - All 9 versions
JM Weinberg - Kidney international, 2006 - nature.com Excess fatty acids accompanied by triglyceride accumulation in parenchymal cells
of multiple tissues including skeletal and cardiac myocytes, hepatocytes, and
pancreatic beta cells results in chronic cellular dysfunction and injury. ... Cited by 47 - Related articles - BL Direct - All 3 versions
A Takahashi, K Motomura, T Kato, T … - Diabetes, 2005 - Am Diabetes Assoc Influx of excess fatty acids and the resultant accumulation of intracellular
triglycerides are linked to impaired insulin secretion and action in the
pathogenesis of type 2 diabetes. Sterol regulatory element-binding protein ( ... Cited by 43 - Related articles - All 5 versions
R Buettner, J Schölmerich, LC Bollheimer - Obesity, 2007 - nature.com Research Methods and Procedures: High-fat (HF) diet feeding can induce obesity
and metabolic disorders in rodents that resemble the human metabolic syndrome.
However, this dietary intervention is not standardized, and the HF-induced ... Cited by 40 - Related articles - All 3 versions
M Dubois, J Kerr-Conte, V Gmyr, T … - Diabetologia, 2004 - Springer Aims/hypothesis. Whether excess glucose (glucotoxic- ity) and excess
non-esterified fatty acids (lipotoxicity) act synergistically or separately to
alter beta-cell func- tion on Type 2 diabetes remains controversial. We ex- ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in
hormone-sensitive lipase-null mice (HSL −/− ), both in vivo and in vitro.
The focus of the current study was to gain further insight into the ... Cited by 34 - Related articles - BL Direct - All 6 versions
RL Hull, K Kodama, KM Utzschneider, DB … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Increased dietary fat intake is associated with
obesity and insulin resistance, but studies have shown that the subsequent
increase in insulin release is not appropriate for this obesity-induced ... Cited by 23 - Related articles - BL Direct - All 3 versions
