- ►asnjournals.org DJ Kelly, A Chanty, RM Gow, Y Zhang, RE … - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol Tubulointerstitial macrophage accumulation is an important marker of prognosis
that correlates closely with declining renal function in a range of human and
experimental diseases, including diabetic nephropathy. These inflammatory ... Cited by 47 - Related articles - All 6 versions
- ►physiology.org S Varma, BK Lal, R Zheng, JW Breslin, S … - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc Diabetes mellitus is a major risk factor for the development of vascular
complications. We hypothesized that hyperglycemia decreases endothelial cell
(EC) proliferation and survival via phosphatidylinositol 3-kinase (PI3k) ... Cited by 29 - Related articles - BL Direct - All 6 versions
RV Haberberger, N Bernardini, M Kress, P … - Autonomic Neuroscience: Basic and Clinical, 2004 - Elsevier Stimulation of nicotinic acetylcholine receptors (nAChR) excites peripheral
sensory nerve fibres, but also exert antinociceptive effects. The differences in
these nAChR-mediated effects could be related to the expression of ... Cited by 24 - Related articles - All 13 versions
K Uehara, SI Yamagishi, S Otsuki, S Chin, S … - Diabetes, 2004 - Am Diabetes Assoc We explored the specific impact of polyol pathway hyperactivity on dorsal root
ganglia (DRG) using transgenic mice that overexpress human aldose reductase
because DRG changes are crucial for the development of diabetic sensory ... Cited by 19 - Related articles - BL Direct - All 4 versions
A Avignon, A Sultan - Diabetes and Metabolism, 2006 - Elsevier PKC comprises a superfamily of isoenzymes that is activated in response to
various stimuli. Hyperglycaemia induces the activation of different PKC
isoforms. However, the PKC-β isoform appears to be preferentially ... Cited by 21 - Related articles - BL Direct - All 3 versions
C Toth, V Brussee, C Cheng, DW Zochodne - Journal of Neuropathology & Experimental Neurology, 2004 - journals.lww.com Sensory neurons in diabetes may be primarily targeted by diabetes and their
involvement may account for prominent sensory loss and pain in diabetic
patients. Previous studies demonstrating evidence of excessive polyol flux, ... Cited by 16 - Related articles - BL Direct - All 4 versions
CS Patil, VP Singh, S Singh, SK Kulkarni - Pharmacology, 2004 - content.karger.com Diabetic neuropathy is one of the most frequent peripheral neuropathies
associated with hyperalgesia and hyperesthesia. Besides alteration in the levels
of neurotransmitter, alteration in the neuronal nitric oxide synthase ... Cited by 15 - Related articles - BL Direct - All 6 versions
T Sasase, H Yamada, K Sakoda, N Imagawa, T … - Diabetes Obes. Metab, 2005 - interscience.wiley.com Aim: Activation of protein kinase C (PKC) is thought to play an important role
in the pathogenesis of diabetic microvascular complications. PKC-β is elevated
in hyperglycaemic conditions, both in vivo and in vitro. In this study, ... Cited by 8 - Related articles - BL Direct - All 4 versions
A Vinik - Expert Opin. Investig. Drugs, 2005 - Informa Pharma Science The potential for addressing the underlying biological abnormalities in dia-
betes has eluded most investigators because of the complex mechanisms underlying
the effects of diabetes on the pathogenesis of the complications. Although ... Cited by 7 - Related articles - BL Direct - All 4 versions
SW Gumułka - Pharmacology, 2008 - content.karger.com [1, 2]. A combination of metabolic and vascular defects has been implicated
inthe pathogenesisofDN. Hypergly- cemia (especially long-lasting) belongs to
basic factors determining the development of DN. Hyperglycemia not only ... Cited by 7 - Related articles - BL Direct - All 7 versions
