P Kougias, H Chai, PH Lin, Q Yao, AB … - Journal of Surgical Research, 2005 - Elsevier Adipose tissue has recently emerged as an active endocrine organ that secretes a
variety of metabolically important substances, collectively called
adipocytokines or adipokines. In this review we summarize the effects of ... Cited by 109 - Related articles - All 15 versions
J Beltowski - Atherosclerosis, 2006 - Elsevier Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is
primarily involved in the regulation of food intake and energy expenditure.
Leptin receptors are expressed in many tissues including the cardiovascular ... Cited by 92 - Related articles - All 18 versions
HK Vincent, AG Taylor - International Journal of Obesity, 2005 - nature.com Oxidative stress may be the unifying mechanism underlying the development of
comorbidities in obesity. Evidence suggests that a clustering of sources of
oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, ... Cited by 89 - Related articles - BL Direct - All 5 versions
ML de Gusmao Correia, WG Haynes - Current opinion in nephrology and hypertension, 2004 - journals.lww.com Recent findings: Leptin possesses cardio-renal actions potentially contributing
to obesity-related hypertension including generalized sympathoactivation.
However, given that leptin resistance occurs in obesity, it has been ... Cited by 78 - Related articles - BL Direct - All 9 versions
F Peelman, W Waelput, H Iserentant, D … - Progress in Lipid Research, 2004 - Elsevier Leptin was originally discovered as an adipocyte-derived hormone involved in the
central control of body weight and energy homeostasis. It is now clear that
leptin is a pleiotropic cytokine, with activities on many peripheral cell ... Cited by 77 - Related articles - All 2 versions
L Li, JC Mamputu, N Wiernsperger, G Renier - Diabetes, 2005 - Am Diabetes Assoc Accumulating evidence suggests that high concentrations of leptin observed in
obesity and diabetes may contribute to their adverse effects on cardiovascular
health. Metformin monotherapy is associated with reduced macrovascular ... Cited by 62 - Related articles - All 5 versions
- ►ahajournals.org H Katagiri, T Yamada, Y Oka - Circulation research, 2007 - Am Heart Assoc Obesity, a major healthcare issue, is associated with significant cardiovascular
morbidities, including hypertension and atherosclerosis. Numerous intensive
studies conducted this decade have revealed that adipose tissue is a major ... Cited by 49 - Related articles - All 6 versions
- ►leptiprorx.com [PDF] MLG Correia, K Rahmouni - Diabetes, Obesity & Metabolism, 2006 - pt.wkhealth.com Results: Hyperleptinaemia is common in obesity and reflects increased adiposity
and leptin resistance. Nevertheless, leptin resistance may not be complete as
several actions of leptin, such as cardiovascular sympatho-activation, ... Cited by 43 - Related articles - BL Direct - All 14 versions
V Sharma, JH McNeill - Current Vascular Pharmacology, 2005 - ingentaconnect.com Abstract: Leptin and ghrelin are novel peptide hormones which are
counter-regulatory in the central control of appetite. More recently, it has
become clear that these hormones have a range of effects on the ... Cited by 26 - Related articles - All 2 versions
- ►cardiovascres.org T Pulinilkunnil, B Rodrigues - Cardiovascular research, 2006 - cardiovascres.org The heart has a limited potential to synthesize fatty acid (FA), and, therefore,
FA is supplied from several sources: lipolysis of endogenous cardiac
triglyceride (TG) stores or from exogenous sources in the blood. ... Cited by 19 - Related articles - All 6 versions
