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Scholar Results 1 - 10 of about 55 citing Huang: Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons.... (0.09 sec) 

Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed …


AM Vincent, JA Olzmann, M Brownlee, WI … - Diabetes, 2004 - Am Diabetes Assoc
The central role of mitochondria in most pathways leading to programmed cell
death (PCD) has focused our investigations into the mechanisms of
glucose-induced neuronal degeneration. It has been postulated that ...
Cited by 72 - Related articles - BL Direct - All 4 versions

Direct insulin signaling of neurons reverses diabetic neuropathy

- diabetesjournals.org
V Brussee, FA Cunningham, DW Zochodne - Diabetes, 2004 - Am Diabetes Assoc
Diabetic polyneuropathy is the most common acquired diffuse disorder of the
peripheral nervous system. It is generally assumed that insulin benefits human
and experimental diabetic neuropathy indirectly by lowering glucose levels. ...
Cited by 66 - Related articles - BL Direct - All 5 versions

[PDF] The role of growth factors in diabetic peripheral neuropathy


GM Leinninger, AM Vincent, EL Feldman - Journal of the peripheral nervous system, 2004 - etc.leinninger.com
Abstract Peripheral neuropathy afflicts 60% of all diabetic patients. Underlying
the clinical disorder is the loss or degeneration of neurons, Schwann cells, and
neuronal fibers. This degenerative pathology has prompted interest in the ...
Cited by 55 - Related articles - View as HTML - BL Direct - All 4 versions

Evaluation of orally active poly (ADP-ribose) polymerase inhibitor in streptozotocin-diabetic …

- inotekcorp.com [PDF] 
F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer
Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ...
Cited by 38 - Related articles - BL Direct - All 11 versions

Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome C …

- jbc.org
MA Di Noia, S Van Driesche, F Palmieri, LM … - Journal of Biological Chemistry, 2006 - ASBMB
Up-regulation of heme oxygenase (HO-1) by either cobalt protoporphyrin (CoPP) or
human gene transfer improves vascular and renal function by several mechanisms,
including increases in antioxidant levels and decreases in reactive oxygen ...
Cited by 34 - Related articles - BL Direct - All 4 versions

Insulin enhances mitochondrial inner membrane potential and increases ATP levels through …


TJ Huang, A Verkhratsky, P Fernyhough - Molecular and Cellular Neuroscience, 2005 - Elsevier
We tested the hypothesis that neurotrophic factors control neuronal metabolism
by directly regulating mitochondrial function in the absence of effects on
survival. Real-time whole cell fluorescence video microscopy was utilized ...
Cited by 32 - Related articles - All 6 versions

Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathy


GM Leinninger, JL Edwards, MJ Lipshaw, EL … - Nature Clinical Practice Neurology, 2006 - nature.com
Eva L Feldman received her MD and Ph.D. in Neuroscience at the University of
Michigan, Ann Arbor, MI, USA and completed her residency in Neurology at the
Johns Hopkins Hospital, Baltimore, PA, USA. She returned to the University ...
Cited by 26 - Related articles - BL Direct - All 3 versions

Remote neurotrophic support of epidermal nerve fibres in experimental diabetes


C Toth, V Brussee, DW Zochodne - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis: The support of distal regen- erating axons and
epidermal nerve fibres through growth factor delivery may depend on the site of
delivery. While low-dose systemic insulin provides trophic support for ...
Cited by 25 - Related articles - BL Direct - All 3 versions

A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor { …

- jbc.org
X Wang, N Li, B Liu, H Sun, T Chen, H Li, J … - Journal of Biological Chemistry, 2004 - ASBMB
The phosphatidylethanolamine (PE)-binding proteins (PEBPs) are an evolutionarily
conserved family of proteins with pivotal biological functions. Here we describe
the cloning and functional characterization of a novel family member, human ...
Cited by 25 - Related articles - BL Direct - All 4 versions

Impaired peripheral nerve regeneration in diabetes mellitus


JM Kennedy, DW Zochodne - J Peripher Nerv Syst, 2005 - interscience.wiley.com
Abstract Diabetes mellitus impairs peripheral nerve regeneration. Regenerative
failure likely exacerbates deficits from polyneuropathy or focal neuropathies in
patients who might otherwise exhibit spontaneous improvement. Some focal ...
Cited by 27 - Related articles - BL Direct - All 3 versions


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