- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
- ►diabetesjournals.org [PDF] JF Ascaso, S Pardo, JT Real, RI Lorente, A Priego, … - Diabetes Care, 2004 - Am Diabetes Assoc In 1998, the American Diabetes Associ- ation (ADA) announced an ambitious 5-year plan for
funding research, namely that by Fiscal Year 2003, one of three Total Public Support dollars
raised by the ADA would be allocated to Re- search Awards and Grants. Since 1998, I ... Cited by 88 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org H Oberkofler, V Linnemayr, R Weitgasser, K Klein, M … - Diabetes, 2004 - Am Diabetes Assoc Peroxisome proliferator–activated receptor coactivator-1α (PGC-1α) is a transcriptional coactivator
implicated in transcriptional programs of hepatic gluconeogenesis, oxidative
phosphorylation, and insulin release by β-cells. To study associations of the PGC-1α ... Cited by 65 - Related articles - BL Direct - All 4 versions
GH Gibbons, CC Liew, MO Goodarzi, JI Rotter, WA … - Circulation, 2004 - Am Heart Assoc From the Cardiovascular Research Institute (GHG), Morehouse School of Medicine, Atlanta,
Ga; the Department of Medicine (CCL, RP, VJD), Brigham and Women's Hospital, Boston,
Mass; Medical Genetics Institute (MOG, JIR), Departments of Pediatrics and Medicine, ... Cited by 57 - Related articles - BL Direct - All 7 versions
- ►usda.gov [PDF] MM Swarbrick, IT Austrheim-Smith, KL Stanhope, MD … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis In addition to weight loss, bariatric sur- gery for severe obesity dramatically
alleviates insulin resistance. In this study, we investigated whether circulating concentrations
of the high-molecular-weight (HMW) form of adiponectin are increased following gastric ... Cited by 48 - Related articles - All 5 versions
SS Rich, DW Bowden, SM Haffner, JM Norris, MF Saad … - Diabetes, 2004 - Am Diabetes Assoc Genetic and environmental determinants play critical roles in insulin resistance and β-cell
function. A model of the complex feedback system for maintenance of glucose tolerance has
been developed that reflects the constraint of glycemia within narrow physiologic limits. ... Cited by 36 - Related articles - BL Direct - All 4 versions
M Laakso - Current opinion in lipidology, 2004 - journals.lww.com Recent findings: Common polymorphisms in the PC-1, insulin receptor substrate 1 and 2, and
PPAR-γ2 genes have been linked to insulin resistance and dyslipidaemia, although the results
have not been consistent. However, the Pro12Pro genotype of the PPAR-γ2 gene has ... Cited by 30 - Related articles - BL Direct - All 6 versions
- ►endojournals.org DM Sengstock, PV Vaitkevicius, MA … - Journal of Clinical …, 2005 - Endocrine Soc Hypertension, diabetes, obesity, and aging are associated with increased arterial stiffness. Both
insulin resistance and hyperglycemia may contribute to the development of arterial stiffness.
Older nondiabetic hypertensive adults were recruited to test the following hypotheses: (1) ... Cited by 23 - Related articles - All 5 versions
- ►diabetesjournals.org E Zeggini, J Parkinson, S Halford, KR Owen, TM … - Diabetes, 2004 - Am Diabetes Assoc The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate
for a contributory role in type 2 diabetes susceptibility. Indeed, functional studies have implicated
the G971R variant, and a recent meta-analysis of 27 association studies suggested that ... Cited by 17 - Related articles - BL Direct - All 5 versions
- ►physiology.org KM Krudys, MG Dodds, SM Nissen, P … - American Journal of …, 2005 - Am Physiological Soc We have developed a new model to describe endogenous glucose kinetics during a labeled
(hot) intravenous glucose tolerance test (IVGTT) to derive a time profile of endogenous glucose
production (EGP). We reanalyzed data from a previously published study (P. Vicini, JJ ... Cited by 8 - Related articles - All 4 versions
