SB Jørgensen, JN Nielsen, JB Birk, GS Olsen, B Viollet, … - Diabetes, 2004 - Am Diabetes Assoc The 5'AMP-activated protein kinase (AMPK) is a potential antidiabetic drug target. Here we show
that the pharmacological activation of AMPK by 5-aminoimidazole-1-ß-4-carboxamide ribofuranoside
(AICAR) leads to inactivation of glycogen synthase (GS) and phosphorylation of GS at Ser ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►jbc.org W Cao, QF Collins, TC Becker, J Robidoux, EG … - Journal of Biological …, 2005 - ASBMB Hepatic gluconeogenesis is essential for maintaining blood glucose levels during fasting and
is the major contributor to postprandial and fasting hyperglycemia in diabetes. Gluconeogenesis
is a classic cAMP/protein kinase A-dependent process initiated by glucagon, which is ... Cited by 40 - Related articles - BL Direct - All 5 versions
Y Xiong, QF Collins, J An, E Lupo, HY Liu, D Liu, J … - Journal of Biological …, 2007 - ASBMB Hepatic lipogenesis is the principal route to convert excess carbohydrates into fatty acids and
is mainly regulated by two opposing hormones, insulin and glucagon. Although insulin stimulates
hepatic lipogenesis, glucagon inhibits it. However, the mechanism by which glucagon ... Cited by 19 - Related articles - All 5 versions
- ►physiology.org YC Lai, JT Stuenaes, CH Kuo, J … - American Journal of …, 2007 - Am Physiological Soc Glycogen content and contraction strongly regulate glycogen synthase (GS) activity, and the
aim of the present study was to explore their effects and interaction on GS phosphorylation and
kinetic properties. Glycogen content in rat epitrochlearis muscles was manipulated in ... Cited by 5 - Related articles - BL Direct - All 3 versions
NF Wiernsperger - Diabetes and Metabolism, 2005 - Elsevier Several decades of research for treating type 2 diabetes have yielded new drugs but the actual
experience with the available oral antidiabetic compounds clearly shows that therapeutic needs
are not matched. This highlights the urgent need for exploring other pathways. All cell ... Cited by 5 - Related articles - BL Direct - All 3 versions
M Montori-Grau, M Guitart, C Lerin, AL … - Biochemical …, 2007 - pubmedcentral.nih.gov Glycogen-targeting PP1 (protein phosphatase 1) subunit G L (coded for by the PPP1R3B
gene) is expressed in human, but not rodent, skeletal muscle. Its effects on muscle glycogen
metabolism are unknown. We show that G L mRNA levels in primary cultured human ... Cited by 3 - Related articles - BL Direct - All 9 versions
DB Savage, L Zhai, B Ravikumar, CS Choi, JE … - PLoS …, 2008 - medicine.plosjournals.org In this study we found a similar prevalence of the variant in an independent UK white population
of 744 participants (1.46%) and, using in vivo 13 C magnetic resonance spectroscopy
studies, demonstrate that human carriers (n = 6) of the variant have low basal (65% lower, ... Cited by 1 - Related articles - Cached - All 11 versions
HQ Qu, C Polychronakos - Diabetes in Women: Pathophysiology and Therapy, 2009 - Springer Genetic susceptibility to type 1 diabetes (DM1) and type 2 diabetes (DM2) is determined by complex
genetic factors. Until recently, only a few loci were known, but this is changing rapidly as a result
of the development of high-density genotyping arrays that have permitted genome-wide ... Related articles - All 2 versions