W Zhang, S Patil, B Chauhan, S Guo, DR Powell, J … - Journal of Biological …, 2006 - ASBMB Page 1. 1 FOXO1 REGULATES MULTIPLE METABOLIC PATHWAYS IN THE LIVER: EFFECTS
ON GLUCONEOGENIC, GLYCOLYTIC AND LIPOGENIC GENE EXPRESSION Wenwei Zhang
1,2 , Sandip Patil 1,2 , Balwant Chauhan 1,2 , Shaodong Guo 1,2 , David R. Powell 3 , ... Cited by 102 - Related articles - BL Direct - All 5 versions
- ►nih.gov CM Taniguchi, K Ueki, CR Kahn - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Hepatic insulin resistance is a critical component in the development of type 2 diabetes
mellitus. In many cases, insulin resistance in liver is associated with reduced expression of both
major insulin receptor substrate (IRS) proteins, IRS-1 and IRS-2. To investigate the ... Cited by 88 - Related articles - All 10 versions
- ►jbc.org JM Schattenberg, Y Wang, R Singh, RM Rigoli, MJ … - Journal of Biological …, 2005 - ASBMB Insulin resistance and increased cytochrome P450 2E1 (CYP2E1) expression are both associated
with and mechanistically implicated in the development of nonalcoholic fatty liver disease. Although
currently viewed as distinct factors, insulin resistance and CYP2E1 expression may be ... Cited by 89 - Related articles - All 4 versions
CZ Larter, GC Farrell - Journal of hepatology, 2006 - Elsevier In community studies, NAFLD correlates with central adiposity, obesity, insulin resistance, and
the complications of insulin resistance—the metabolic syndrome and type 2 diabetes mellitus
[1] and [2]. Studies of histologically confirmed NASH show a near universal association ... Cited by 58 - Related articles - All 6 versions
- ►ebmonline.org RV Farese, MP Sajan, ML Standaert - Experimental Biology and Medicine, 2005 - SEBM Glucose transport into muscle is the initial process in glucose clearance and is uniformly defective
in insulin-resistant conditions of obesity, metabolic syndrome, and Type II diabetes mellitus. Insulin
regulates glucose transport by activating insulin receptor substrate-1 (IRS-1)–dependent ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►nih.gov X Dong, S Park, X Lin, K Copps, X Yi, … - Journal of Clinical …, 2005 - Am Soc Clin Investig Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals
with heterologous pathways to coordinate growth and metabolism. Since Irs2 is thought to be
especially important in hepatic nutrient homeostasis, we deleted Irs1 from hepatocytes of ... Cited by 37 - Related articles - BL Direct - All 12 versions
- ►nih.gov RV Farese, MP Sajan, H Yang, P Li, S … - Journal of Clinical …, 2007 - Am Soc Clin Investig 1 James A. Haley Veterans Medical Center, Tampa, Florida, USA. 2 Roskamp Institute,
Sarasota, Florida, USA. 3 Department of Internal Medicine and Department of Molecular
Medicine, University of South Florida College of Medicine, Tampa, Florida, USA. 4 ... Cited by 34 - Related articles - BL Direct - All 8 versions
R Farese, M Sajan, M Standaert - Biochemical Society …, 2005 - bst.portlandpress.com It now seems clear that aPKC (atypical protein kinase C) isoforms are required for insulin-stimulated
glucose transport in muscle and adipocytes. Moreover, there are marked defects in the activation
of aPKCs under a variety of insulin-resistant conditions in humans, monkeys and rodents. ... Cited by 34 - Related articles - Cached - All 9 versions
ML Standaert, MP Sajan, A Miura, Y Kanoh, HC … - Journal of Biological …, 2004 - ASBMB Insulin resistance in type 2 diabetes is characterized by defects in muscle glucose uptake and
hepatic overproduction of both glucose and lipids. These hepatic defects are perplexing because
insulin normally suppresses glucose production and increases lipid synthesis in the liver. ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►amjpathol.org M Boissan, E Beurel, D Wendum, C Rey, Y Lecluse, … - American Journal of …, 2005 - ASIP Deregulations in insulin and insulin-like growth factor (IGF) pathways may contribute to hepatocellular
carcinoma. Although intracellular insulin receptor substrate-2 (IRS-2) is the main effector of insulin
signaling in the liver, its role in hepatocarcinogenesis is unknown. Here, we show that ... Cited by 26 - Related articles - BL Direct - All 7 versions
