- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Maedler, DM Schumann, N Sauter, H … - Diabetes, 2006 - Am Diabetes Assoc High glucose concentrations have a dual effect on β-cell turnover, inducing
proliferation in the short-term and apoptosis in the long-term. Hyperglycemia
leads to β-cell production of interleuking (IL)-1β in human pancreatic ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N … - Endocrine Reviews, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro
discovery in 1984, evolving via descriptive and phenomenological studies to
detailed mapping of the signalling pathways, gene- and protein expression ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org J Yang, CE Robert, BR Burkhardt, RA Young, … - Diabetes, 2005 - Am Diabetes Assoc Pancreatic-derived factor (PANDER) is an islet-specific cytokine present in both
pancreatic α- and β-cells, which, in vitro, induces β-cell apoptosis of
primary islet and cell lines. In this study, we investigated whether PANDER ... Cited by 15 - Related articles - BL Direct - All 5 versions
BR Burkhardt, MC Yang, CE Robert, SR … - BBA-Gene Structure and Expression, 2005 - Elsevier Pancreatic derived factor (PANDER) is a recently identified cytokine-like
protein that is dominantly expressed in the islets of Langerhans of the
pancreas. To investigate the mechanism of tissue-specific regulation of ... Cited by 12 - Related articles - All 4 versions
- ►physiology.org X Cao, J Yang, BR Burkhardt, Z Gao, RK … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc PANcreatic DERived factor (PANDER, FAM3B) is a recently discovered
islet-specific cytokine. We have previously shown that, in vitro, truncated
recombinant PANDER isoforms (20 and 21 kDa) are cytotoxic to -cell lines ... Cited by 11 - Related articles - BL Direct - All 4 versions
SB Narayan, D Rakheja, JV Pastor, K … - Molecular genetics and metabolism, 2006 - Elsevier Juvenile neuronal ceroid-lipofuscinosis (JNCL) or
Batten/Spielmeyer–Vogt–Sjogren disease (OMIM #204200) is one of a group of
nine clinically related inherited neurodegenerative disorders (CLN1–9). ... Cited by 10 - Related articles - All 4 versions
K Maedler, DM Schumann, N Sauter, H … - Diabetes, 2006 - Am Diabetes Assoc T he capacity of the pancreatic -cell to adaptively increase insulin secretion
in response to long- term insulin resistance (for example in obesity) is
fundamental to the maintenance of normogly- cemia. Failure of such a ... Cited by 9 - Related articles - All 3 versions
T Lund, B Fosby, O Korsgren, H Scholz, A … - Transplant International, 2008 - interscience.wiley.com Factors that upregulate the inflammatory status of islets probably contribute to
detrimental processes leading to islet loss and impaired post-transplant
function. Glucocorticoids have the potential to counteract inflammation and ... Cited by 6 - Related articles - All 3 versions
- ►endojournals.org O Wang, K Cai, S Pang, T Wang, D Qi, Q Zhu, … - Endocrinology, 2008 - Endocrine Soc Pancreatic-derived factor (PANDER) is a cytokine-like peptide highly expressed
in pancreatic β-cells. PANDER was reported to promote apoptosis of pancreatic
β-cells and secrete in response to glucose. Here we explored the effects ... Cited by 4 - Related articles - BL Direct - All 4 versions
