- ►diabetesjournals.org J Mu, J Woods, YP Zhou, RS Roy, Z Li, E … - Diabetes, 2006 - Am Diabetes Assoc Inhibitors of dipeptidyl peptidase-4 (DPP-4), a key regulator of the actions of
incretin hormones, exert antihyperglycemic effects in type 2 diabetic patients.
A major unanswered question concerns the potential ability of DPP-4 ... Cited by 126 - Related articles - BL Direct - All 9 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many
different elements that act in concert to cause that disease. This review
proposes a sequence of events and how they interact by a careful analysis ... Cited by 102 - Related articles - All 14 versions
JJ Meier, A Bhushan, AE Butler, RA Rizza, PC … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Type 1 diabetes is widely held to result from an
irreversible loss of insulin-secreting beta cells. However, insulin secretion is
detectable in some peo- ple with long-standing type 1 diabetes, indicating ... Cited by 103 - Related articles - BL Direct - All 5 versions
- ►escholarship.org AE Butler, J Jang, T Gurlo, MD Carty, WC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass,
increased β-cell apoptosis, and impaired insulin secretion. Also, islets in
type 2 diabetes often contain deposits of islet amyloid derived from islet ... Cited by 93 - Related articles - BL Direct - All 9 versions
- ►upenn.edu [PDF] M Teta, MM Rankin, SY Long, GM Stein, JA … - Developmental cell, 2007 - Elsevier Cellular progenitors remain poorly characterized in many adult tissues, limited
in part by the lack of unbiased techniques to identify progenitors and their
progeny. To address this fundamental problem, we developed a novel DNA ... Cited by 88 - Related articles - All 12 versions
HA Lashuel, PT Lansbury - Quarterly reviews of biophysics, 2006 - Cambridge Univ Press Abstract. Protein fibrillization is implicated in the pathogenesis of most, if
not all, age- associated neurodegenerative diseases, but the mechanism(s) by
which it triggers neuronal death is unknown. Reductionist in vitro studies ... Cited by 76 - Related articles - BL Direct - All 3 versions
- ►physiology.org LM Dickson, CJ Rhodes - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The control of pancreatic -cell growth and survival in the adult plays a pivotal
role in the pathogenesis of type 2 diabetes. In certain insulin-resistant
states, such as obesity, the increased insulin-secretory demand can often ... Cited by 58 - Related articles - BL Direct - All 3 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a
common cause of cell attrition in diseases characterized by misfolding and
oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is ... Cited by 55 - Related articles - BL Direct - All 5 versions
PM Gholam, L Flancbaum, JT Machan, DA … - American Journal of Gastroenterology, 2007 - medscape.com The rapid rise in the prevalence of overweight and obesity in the United States
and its implications on public health are now a regular fixture in the lay
press. Poor diet and physical inactivity are second only to tobacco use as ... Cited by 49 - Related articles - BL Direct - All 9 versions
JD Green, C Goldsbury, J Kistler, GJS Cooper … - Journal of Biological Chemistry, 2004 - ASBMB Human amylin (hA), a 37-amino-acid polypeptide, is one of a number of peptides
with the ability to form amyloid fibrils and cause disease. It is the main
constituent of the pancreatic amyloid deposits associated with type 2 ... Cited by 48 - Related articles - BL Direct - All 4 versions
