A Pocai, TKT Lam, R Gutierrez-Juarez, S Obici, GJ … - Nature, 2005 - nature.com Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes
mellitus 1, 2 . Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic
gluconeogenesis 3 . The medial ... Cited by 154 - Related articles - All 7 versions
- ►yu.edu [PDF] TKT Lam, A Pocai, R Gutierrez-Juarez, S Obici, J … - Nature medicine, 2005 - medscape.com Increased glucose production is a hallmark of type 2 diabetes and alterations in lipid metabolism
have a causative role in its pathophysiology. Here we postulate that physiological increments in
plasma fatty acids can be sensed ... Cited by 118 - Related articles - All 9 versions
- ►cell.com A Pocai, S Obici, GJ Schwartz, L Rossetti - Cell Metabolism, 2005 - Elsevier Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes
mellitus. Previous studies suggested that lipid metabolism within specific hypothalamic nuclei is a
biochemical sensor for nutrient ... Cited by 97 - Related articles - All 9 versions
- ►physiology.org GN Wade, JE Jones - American Journal of Physiology- Regulatory …, 2004 - Am Physiological Soc Natural selection has linked the physiological controls of energy balance and fertility such that
reproduction is deferred during lean times, particularly in female mammals. In this way, an
energetically costly process is ... Cited by 63 - Related articles - All 8 versions
- ►endojournals.org SE la Fleur, SF Akana, SL Manalo, MF Dallman - Endocrinology, 2004 - Endocrine Soc Passive elevations in glucocorticoids result in increased insulin and abdominal obesity with
peripheral wasting, as observed in Cushing's syndrome, with little effect on chow intake. In the
absence of insulin (streptozotocin- ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►endojournals.org F Kreier, YS Kap, TC Mettenleiter, C van Heijningen, J … - Endocrinology, 2006 - Endocrine Soc The hypothalamus uses hormones and the autonomic nervous system to balance energy fluxes in the
body. Here we show that the autonomic nervous system has a distinct organization in different body
compartments. The same neurons ... Cited by 47 - Related articles - BL Direct - All 7 versions
MF Dallman, SF Akana, AM Strack, KS … - ANNALS-NEW …, 2004 - interscience.wiley.com Abstract: Acutely, glucocorticoids act to inhibit stress-induced corticotrophin-releasing factor
(CRF) and adrenocorticotrophic hormone (ACTH) secretion through their actions in brain and anterior
pituitary (canonical feedback). ... Cited by 46 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org Y Ishigaki, H Katagiri, T Yamada, T Ogihara, J Imai, K … - Diabetes, 2005 - Am Diabetes Assoc For examining whether dissipating excess energy in the liver is a possible therapeutic approach to
high-fat diet–induced metabolic disorders, uncoupling protein-1 (UCP1) was expressed in murine
liver using adenoviral vectors in ... Cited by 41 - Related articles - All 5 versions
HR Berthoud - The Anatomical Record, 2004 - interscience.wiley.com Vagal and spinal afferent innervation of the portal hepatic area has not been studied as thoroughly
as the innervation of other important organs. It is generally agreed that unlike noradrenergic
sympathetic efferent nerve fibers, ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►royalsocietypublishing.org B Beck - Philosophical Transactions B, 2006 - rstb.royalsocietypublishing.org Neuropeptide Y (NPY) is one the most potent orexigenic peptides found in the brain. It stimulates
food intake with a preferential effect on carbohydrate intake. It decreases latency to eat,
increases motivation to eat and ... Cited by 19 - Related articles - BL Direct - All 10 versions
