AM Vincent, JA Olzmann, M Brownlee, WI Sivitz, JW … - Diabetes, 2004 - Am Diabetes Assoc The central role of mitochondria in most pathways leading to programmed cell death (PCD) has
focused our investigations into the mechanisms of glucose-induced neuronal degeneration.
It has been postulated that hyperglycemic neuronal injury results from mitochondria ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org V Brussee, FA Cunningham, DW Zochodne - Diabetes, 2004 - Am Diabetes Assoc Diabetic polyneuropathy is the most common acquired diffuse disorder of the peripheral nervous
system. It is generally assumed that insulin benefits human and experimental diabetic neuropathy
indirectly by lowering glucose levels. Insulin also provides potent direct support of ... Cited by 66 - Related articles - BL Direct - All 5 versions
GM Leinninger, AM Vincent, EL … - Journal of the peripheral …, 2004 - etc.leinninger.com Abstract Peripheral neuropathy afflicts 60% of all diabetic patients. Underlying the clinical disorder
is the loss or degeneration of neurons, Schwann cells, and neuronal fibers. This degenerative
pathology has prompted interest in the potential of growth factors as a therapy in diabetic ... Cited by 55 - Related articles - View as HTML - BL Direct - All 4 versions
E Ho, KSL Lam, YS Chen, JCW Yip, M Arvindakshan, … - Diabetes, 2006 - Am Diabetes Assoc The exaggerated flux through polyol pathway during diabetes is thought to be a major cause
of lesions in the peripheral nerves. Here, we used aldose reductase (AR)-deficient (AR −/− )
and AR inhibitor (ARI)-treated mice to further understand the in vivo role of polyol ... Cited by 31 - Related articles - BL Direct - All 7 versions
IG Obrosova, UA Julius - Current Vascular Pharmacology, 2005 - ingentaconnect.com Abstract: Chronic complications of diabetes mellitus ea diabetic nephropathy, neuropathy and
retinopathy develop in at least 30-50% of patients with both Type 1 (insulin-dependent) and Type
2 (non-insulin-dependent) diabetes, and are the major cause of increased morbidity and ... Cited by 22 - Related articles - All 2 versions
JM Kennedy, DW Zochodne - Diabetes, 2005 - Am Diabetes Assoc Progressive diabetic neuropathy has hitherto been irreversible in humans. New approaches
raise the question of whether islet cell reconstitution rendering euglycemia can reverse specific
features of neuropathy. We evaluated physiological and structural features of ... Cited by 20 - Related articles - All 5 versions
- ►nih.gov JA Christianson, JM Ryals, MS Johnson, RT … - Neuroscience, 2007 - Elsevier Human diabetic patients often lose touch and vibratory sensations, but to date, most studies on
diabetes-induced sensory nerve degeneration have focused on epidermal C-fibers. Here, we
explored the effects of diabetes on cutaneous myelinated fibers in relation to the ... Cited by 17 - Related articles - All 5 versions
C Toth, V Brussee, C Cheng, DW … - Journal of Neuropathology …, 2004 - journals.lww.com Sensory neurons in diabetes may be primarily targeted by diabetes and their involvement may
account for prominent sensory loss and pain in diabetic patients. Previous studies demonstrating
evidence of excessive polyol flux, microangiopathy, and oxidative stress involving ... Cited by 17 - Related articles - BL Direct - All 4 versions
R Perez-Olle, MA Lopez-Toledano, RKH … - Journal of Neuropathology …, 2004 - journals.lww.com Abstract. The human neurofilament medium (hNFM) subunit is one of the 3 neurofilament
(NF) polypeptides, which are the most abundant intermediate filament (IF) proteins in post-mitotic
neurons. The formation of neurofilamentous aggregates is a pathological hallmark of ... Cited by 15 - Related articles - BL Direct - All 5 versions
A Berent-Spillson, AM Robinson, D … - Journal of …, 2004 - interscience.wiley.com Glutamate carboxypeptidase II (GCP II) inhibition has previously been shown to be protective
against long-term neuropathy in diabetic animals. In the current study, we have determined that
the GCP II inhibitor 2-(phosphonomethyl) pentanedioic acid (2-PMPA) is protective ... Cited by 14 - Related articles - BL Direct - All 5 versions
