- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
AL Gloyn - Human mutation, 2003 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a
crucial role in the regulation of insulin secretion and has been termed the
pancreatic beta-cell sensor. Given its central role in the regulation of ... Cited by 121 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org FM Matschinsky, MA Magnuson, D Zelent, TL … - Diabetes, 2006 - Am Diabetes Assoc The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and
molecular genetic features that are ideal for its primary role as glucose sensor
in a network of neuro/endocrine sentinel cells that maintain glucose ... Cited by 75 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org AL Cuesta-Muñoz, H Huopio, T Otonkoski, JM … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor
in the pancreatic β-cell, where it governs glucose-stimulated insulin secretion
(GSIS). Heterozygous inactivating mutations in the glucokinase gene (GCK) ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 56 - Related articles - BL Direct - All 5 versions
D Zelent, H Najafi, S Odili, C Buettger, H Weik … - Biochemical Society Transactions, 2005 - bst.portlandpress.com The enzyme GK (glucokinase), which phosphorylates glucose to form glucose
6-phosphate, serves as the glucose sensor of insulin-producing b-cells. GK has
thermodynamic, kinetic, regulatory and molecular genetic characteristics ... Cited by 42 - Related articles - Cached - All 9 versions
AT Hattersley, ER Pearson - Endocrinology, 2006 - Endocrine Soc Defining the molecular genetics of diabetes gives new insight into the
underlying etiology and so should help improve treatment. The genetic etiology
is now known for most patients with ß-cell monogenic diabetes, allowing ... Cited by 43 - Related articles - BL Direct - All 8 versions
- ►cell.com P Akpinar, S Kuwajima, J Krützfeldt, M Stoffel - Cell Metabolism, 2005 - Elsevier The signals and molecular mechanisms that regulate the replication of terminally
differentiated β cells are unknown. Here, we report the identification and
characterization of transmembrane protein 27 (Tmem27, collectrin) in ... Cited by 40 - Related articles - All 12 versions
AL Gloyn, J Siddiqui, S Ellard - Human mutation, 2006 - interscience.wiley.com The beta-cell ATP-sensitive potassium channel is a key component of
stimulus-secretion coupling in the pancreatic beta-cell. The channel couples
metabolism to membrane electrical events, bringing about insulin secretion. ... Cited by 32 - Related articles - BL Direct - All 3 versions
AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological Chemistry, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous
inactivating GCK mutations cause hyperglycemia, whereas activating mutations
cause hypoglycemia. We studied the GCK V62M mutation identified in two ... Cited by 31 - Related articles - All 7 versions
