- ►diabetesjournals.org C Pihoker, LK Gilliam, CS Hampe, Å Lernmark - Diabetes, 2005 - Am Diabetes Assoc Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The
appearance of autoantibodies to one or several of the autoantigens—GAD65, IA-2, or
insulin—signals an autoimmune pathogenesis of β-cell killing. A β-cell attack may be best ... Cited by 53 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org P Achenbach, E Bonifacio, K Koczwara, AG Ziegler - Diabetes, 2005 - Am Diabetes Assoc The natural history of autoimmune type 1 diabetes in children is associated with the appearance
of islet autoantibodies early in life, which is influenced by genetic and environmental factors.
Once islet autoantibodies have developed, the progression to diabetes in ... Cited by 37 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org RDG Leslie, MD Castelli - Diabetes, 2004 - Am Diabetes Assoc A decade ago we proposed that environmental factors operating in early life lead to type 1
diabetes, outlining the evidence and the implications if the hypothesis was true (1). Today we
can be confident that environmental factors can indeed operate in childhood to cause ... Cited by 35 - Related articles - BL Direct - All 8 versions
HE Larsson, K Lynch, B Lernmark, A Nilsson, G … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The aim of our study was to test the hypothesis that HLA genotypes
conferring risk of diabetes, cord blood autoantibodies, or both are associated with increased
birthweight. Methods: HLA genotypes were determined in dried blood spots of cord blood ... Cited by 27 - Related articles - BL Direct - All 3 versions
PA Silveira, ST Grey - Trends in Endocrinology & Metabolism, 2006 - Elsevier It has long been established that type 1 diabetes (T1D) is a T cell-mediated autoimmune
disease, with CD4 + and CD8 + T cells being largely responsible for the destruction of β cells
within the pancreatic islets of Langerhans. Although autoantibodies specific for islet cell ... Cited by 24 - Related articles - All 6 versions
H Peng, W Hagopian - Reviews in Endocrine & Metabolic Disorders, 2006 - Springer Abstract Environmental factors appear to play an important role in the pathogenesis of
childhood-onset type 1 diabetes (T1D). The most important factors are thought to be
infectious, dietary, perinatal, and psychosocial. Enterovi- ruses (especially Coxsackie B ... Cited by 23 - Related articles - BL Direct - All 3 versions
K Larsson, H Elding-Larsson, E Cederwall, K … - Diabetes/Metabolism … - interscience.wiley.com The mechanisms by which gestational infections, blood incompatibility, birth weight, mother's
age and other prenatal or neonatal events increase the risk for type 1 diabetes are not
understood. Studies so far have been retrospective, and there is a lack of ... Cited by 21 - Related articles - BL Direct - All 3 versions
CE Taplin, JM Barker - Autoimmunity, 2008 - informahealthcare.com Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial
states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called
juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►nih.gov LR Washburn, H Dang, J Tian, DL Kaufman - Journal of autoimmunity, 2007 - Elsevier When nonobese-diabetic (NOD) mouse embryos were implanted into pseudopregnant mothers
of a nonautoimmune mouse strain, the progeny had a reduced type 1 diabetes (T1D)
incidence, suggesting that transmission of maternal autoantibodies is important for T1D ... Cited by 8 - Related articles - All 5 versions
