RAFM Chamuleau, T Deurholt, R Hoekstra - Metabolic brain disease, 2005 - Springer Anno 2004 freshly isolated or cryopreserved porcine or human hepatocytes have been most
frequently used as biocomponent in clinically applied bioartificial livers (BALs). Phase 1 studies
of all biocomponent modalities showed safety, feasibility, and improvement of bio- ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►multicelltech.com [PDF] M Vermeir, P Annaert, RNVS Mamidi, D … - Expert Opin. Drug …, 2005 - informahealthcare.com Cell-based in vitro models are invaluable tools in elucidating the pharmaco- kinetic profile of
a drug candidate during its drug discovery and development process. As biotransformation is
one of the key determinants of a drug's disposition in the body, many in vitro models to ... Cited by 25 - Related articles - BL Direct - All 7 versions
HS Jun, JW Yoon - Current gene therapy, 2005 - ingentaconnect.com Abstract: Type 1 diabetes results from insulin deficiency caused by autoimmune destruction of
insulin-producing pancre- atic β cells. Islet transplantation, β cell regeneration, and insulin gene
therapy have been explored in an attempt to cure type 1 diabetes. Major progress on islet ... Cited by 20 - Related articles - All 5 versions
T Totsugawa, C Yong, JD Rivas-Carrillo, A Soto- … - Journal of hepatology, 2007 - Elsevier Human hepatocytes were immortalized with a retroviral vector SSR#197 expressing catalytic
subunit of human telomerase reverse transcriptase (hTERT) and enhanced green fluorescent
protein (EGFP) cDNAs flanked by a pair of loxP recombination targets. Then, Tamoxifen- ... Cited by 13 - Related articles - All 11 versions
MJ Liu, S Shin, N Li, T Shigihara, YS Lee, JW Yoon, HS … - Molecular Therapy, 2007 - nature.com Type 1 diabetes results from insulin deficiency caused by destruction of pancreatic cells.
Glucagon-like peptide (GLP)-1 stimulates cell growth and differentiation. To determine whether
continuous expression of GLP-1 in vivo can regenerate cells and remit type 1 diabetes in ... Cited by 9 - Related articles - All 2 versions
H Ikeda, N Kobayashi, Y Tanaka, S Nakaji, C … - Tissue …, 2006 - liebertonline.com Page 1. A Newly Developed Bioartificial Pancreas Successfully Controls Blood Glucose
in Totally Pancreatectomized Diabetic Pigs HIDEAKI IKEDA, MD, 1 NAOYA KOBAYASHI,
MD, Ph.D., 1 YOSHIHITO TANAKA, Ph.D., 2 SHUHEI ... Cited by 8 - Related articles - BL Direct - All 4 versions
M Shinoda, AW Tilles, N Kobayashi, G … - Journal of Surgical …, 2007 - Elsevier Liver transplantation is the treatment of choice for many patients with fulminant hepatic failure
(FHF). A major limitation of this treatment is the lack of available donors. An optimally functioning
bio-artificial liver (BAL) device has the potential to provide critical hepatic support to ... Cited by 8 - Related articles - All 17 versions
- ►nih.gov N Cobbe - British Medical Journal, 2006 - jme.bmj.com In her editorial in the February 2005 issue of this journal, Nikola Biller-Andorno questioned whether
the effort and resources that have been invested in debates about cloning at the United Nations
might have been somewhat disproportionate, if a binding universal agreement on ... Cited by 9 - Related articles - BL Direct - All 11 versions
KKNKT Okitsu, CYTFH Ikeda, YKMNT Arata, N … - Artificial organs - interscience.wiley.com Abstract: Purpose: To develop and evaluate the efficacy of diabetes-targeted cell therapies in
humans, a reliable model in larger animals is highly desirable. This article reports the surgical
technique of total pancreatectomy in pigs and the biochemical analysis of the ... Cited by 6 - Related articles - BL Direct - All 4 versions
