- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 195 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org CJ Nolan, MSR Madiraju, V Delghingaro- … - Diabetes, 2006 - Am Diabetes Assoc Fatty acids (FAs) and other lipid molecules are important for many cellular
functions, including vesicle exocytosis. For the pancreatic β-cell, while the
presence of some FAs is essential for glucose-stimulated insulin secretion, ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in
hormone-sensitive lipase-null mice (HSL −/− ), both in vivo and in vitro.
The focus of the current study was to gain further insight into the ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►jbc.org RL Hurley, LK Barre, SD Wood, KA Anderson, … - Journal of Biological Chemistry, 2006 - ASBMB The AMP-activated protein kinase (AMPK) and cAMP signaling systems are both key
regulators of cellular metabolism. In this study, we show that AMPK activity is
attenuated in response to cAMP-elevating agents through modulation of at ... Cited by 31 - Related articles - All 7 versions
- ►jbc.org KL Pappan, Z Pan, G Kwon, CA Marshall, T … - Journal of Biological Chemistry, 2005 - ASBMB Lipid and glucose metabolism are adversely affected by diabetes, a disease
characterized by pancreatic -cell dysfunction. To clarify the role of lipids in
insulin secretion, we generated mice with -cell-specific overexpression ( ... Cited by 22 - Related articles - All 5 versions
- ►endojournals.org M Fex, CS Olofsson, U Fransson, K Bacos, H … - Endocrinology, 2004 - Endocrine Soc Lipids are thought to serve as coupling factors in insulin secretion.
Hormone-sensitive lipase (HSL) is expressed in pancreatic ß-cells and could
potentially regulate insulin secretion via mobilization of stored ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org TH Claus, DB Lowe, Y Liang, AI Salhanick, CK … - Journal of Pharmacology and Experimental …, 2005 - ASPET Elevation of plasma free fatty acids has been linked with insulin resistance and
diabetes. Inhibition of lipolysis may provide a mechanism to decrease plasma
fatty acids, thereby improving insulin sensitivity. Hormone-sensitive ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Prentki, SR Madiraju - Endocrine reviews, 2008 - Endocrine Soc GL/FFA cycle is referred to as a "futile" cycle because it involves continuous
formation and hydrolysis of GL with the release of heat, at the expense of ATP.
However, we present evidence underscoring the "vital" cellular signaling ... Cited by 14 - Related articles - All 5 versions
U Fransson, AH Rosengren, FC Schuit, E … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: The molecular mechanisms of insulin release are only
partially known. Among putative factors for coupling glucose metabolism to
insulin secretion, anaplerosis has lately received strong support. The ... Cited by 12 - Related articles - BL Direct - All 5 versions
