- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M Ravazzola, … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which may contribute
to the development of type 2 diabetes. The mechanisms involved in FFA-induced cell death are
not completely understood. Here we have investigated the effect of FFA on endoplasmic ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to insufficient insulin secretion
in susceptible individuals, contributing to type 2 diabetes. The molecules mediating this effect
are just beginning to be identified. Uncoupling protein (UCP)-2 may be one such negative ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org MW Fariss, CB Chan, M Patel, B Van Houten, S … - Molecular interventions, 2005 - ASPET Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of
numerous common diseases. The critical mitochondrial events responsible for oxidative
stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. ... Cited by 69 - Related articles - All 2 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary pathogenesis
of diabetes is established, probably involving both genetic and environmental forces, ... Cited by 71 - Related articles - BL Direct - All 7 versions
ZC Luo, WD Fraser, P Julien, CL Deal, F Audibert, GN … - Medical hypotheses, 2006 - Elsevier Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated
with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance,
hypertension), type 2 diabetes and cardiovascular disease in adulthood. The ... Cited by 49 - Related articles - All 27 versions
PC Moore, MA Ugas, DK Hagman, SD Parazzoli, V … - Diabetes, 2004 - Am Diabetes Assoc Prolonged exposure to elevated levels of fatty acids adversely affects pancreatic β-cell
function. Here we investigated 1) whether ceramide synthesis, which we reported to mediate
fatty acid inhibition of insulin gene expression, also inhibits insulin secretion and 2) ... Cited by 43 - Related articles - BL Direct - All 7 versions
G Mattiasson, PG Sullivan - Antioxidants & Redox Signaling, 2006 - liebertonline.com 1 Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund,
Sweden. 2 Spinal Cord and Brain Injury Research Center and 3 Department of Anatomy and
Neurobiology University of Kentucky, Lexington, Kentucky. ... The Emerging Functions of ... Cited by 41 - Related articles - BL Direct - All 3 versions
NK Yashpal, J Li, MB Wheeler, R Wang - Endocrinology, 2005 - Endocrine Soc The integrin receptors link to extracellular matrix proteins and exert a dynamic role in development
by providing the physical basis for cell adhesion and controlling cell growth. In the present
study, we examined changes in the expression of ß1 integrins and its associated ... Cited by 26 - Related articles - All 5 versions
J Chen, G Saxena, IN Mungrue, AJ Lusis, A Shalev - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of INS-1 cells at 25 mmol/l glucose for 24 h led to an 18-fold increase
in TXNIP protein, as assessed by immunoblotting. This was accompanied by increased
apoptosis, as demonstrated by a 12-fold induction of cleaved caspase-3. Overexpression ... Cited by 27 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park, … - Diabetes, 2007 - Am Diabetes Assoc Liver X receptor (LXR)α and LXRβ play important roles in fatty acid metabolism and cholesterol
homeostasis. Although the functional roles of LXR in the liver, intestine, fat, and macrophages
are well established, its role in pancreatic β-cells has not been clearly defined. In this ... Cited by 23 - Related articles - BL Direct - All 6 versions
