- ►physiology.org L Bouwens, I Rooman - Physiological reviews, 2005 - Am Physiological Soc Beta-cell mass regulation represents a critical issue for understanding
diabetes, a disease characterized by a near-absolute (type 1) or relative (type
2) deficiency in the number of pancreatic beta cells. The number of islet ... Cited by 115 - Related articles - BL Direct - All 6 versions
- ►nih.gov JA Kushner, MA Ciemerych, E Sicinska, LM … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol Regulation of adult ß-cell mass in pancreatic islets is essential to preserve
sufficient insulin secretion in order to appropriately regulate glucose
homeostasis. In many tissues mitogens influence development by stimulating ... Cited by 113 - Related articles - All 7 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
GS Hassan, JF Jasmin, W Schubert, PG Frank, … - Biochemistry, 2004 - uphs.upenn.edu ABSTRACT: Neointima formation is a process characterized by smooth muscle cell
(SMC) proliferation and extracellular matrix deposition in the vascular intimal
layer. Here, we critically evaluate the role of caveolin-1 (Cav-1) in the ... Cited by 42 - Related articles - View as HTML - BL Direct - All 6 versions
- ►diabetesjournals.org S Fatrai, L Elghazi, N Balcazar, C Cras- … - Diabetes, 2006 - Am Diabetes Assoc Proliferation is the major component for maintenance of β-cell mass in adult
animals. Activation of phosphoinositide 3-kinase/Akt-kinase pathway is a
critical regulator of β-cell mass. Pancreatic β-cell overexpression of ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►shouxi.net X Zhang, JP Gaspard, Y Mizukami, J Li, F … - Diabetes, 2005 - Am Diabetes Assoc Cyclin D1 can stimulate proliferation by driving cells from the G1 into the
S-phase of the mammalian cell cycle. Previous animal studies have implicated the
G1-S transition as a key regulatory checkpoint governing the proliferation ... Cited by 32 - Related articles - All 5 versions
- ►shouxi.net R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological Chemistry, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and
mass in patients with diabetes is possible. A regenerative approach may
represent an alternative treatment option relative to current diabetes ... Cited by 29 - Related articles - All 7 versions
- ►endocrinology-journals.org MJ Kim, JH Kang, YG Park, GR Ryu, SH Ko, … - Journal of Endocrinology, 2006 - Soc Endocrinology Glucagon-like peptide-1 (GLP-1) and its analog exendin-4 (EX) have been
considered as a growth factor implicated in pancreatic islet mass increase and
ß-cell proliferation. This study aimed to investigate the effect of EX on ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org P Rao, J Roccisana, KK Takane, R Bottino, A … - Diabetes, 2005 - Am Diabetes Assoc Akt is an important intracellular mediator of β-cell growth and survival in
rodents. However, whether constitutive activation of Akt in human β-cells
enhances the survival and function of transplanted islets is unknown. In ... Cited by 19 - Related articles - All 6 versions
- ►nih.gov H Mziaut, S Kersting, KP Knoch, WH Fan, M … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Changes in metabolic demands dynamically regulate the total mass of adult
pancreatic β-cells to adjust insulin secretion and preserve glucose
homeostasis. Glucose itself is a major regulator of β-cell proliferation ... Cited by 15 - Related articles - BL Direct - All 7 versions
