- ►endojournals.org BF Schrijvers, AS De Vriese, A Flyvbjerg - Endocrine reviews, 2004 - Endocrine Soc At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2 diabetic
patients. Several decades of extensive research has elucidated various pathways to be implicated
in the development of diabetic kidney disease. This review focuses on the metabolic ... Cited by 122 - Related articles - All 5 versions
- ►ahajournals.org C Falcone, E Emanuele, A D'Angelo, MP … - … , and vascular biology, 2005 - Am Heart Assoc Methods and Results— Plasma levels of sRAGE were determined in 328 nondiabetic male patients
with angiographically proved CAD and in 328 age-matched healthy controls. The concentration
of sRAGE in plasma was significantly lower (P<0.0001) in CAD cases [median ... Cited by 112 - Related articles - All 11 versions
JM Forbes, SR Thorpe, V Thallas-Bonke, J … - Journal of the American …, 2005 - Am Soc Nephrol Recent studies have identified that first-line renoprotective agents that interrupt the renin-angiotensin
system not only reduce BP but also can attenuate advanced glycation end product (AGE)
accumulation. This study used in vitro, preclinical, and human approaches to explore the ... Cited by 72 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JM Forbes, MT Coughlan, ME Cooper - Diabetes, 2008 - Am Diabetes Assoc It is postulated that localized tissue oxidative stress is a key component in the development of
diabetic nephropathy. There remains controversy, however, as to whether this is an early link
between hyperglycemia and renal disease or develops as a consequence of other ... Cited by 45 - Related articles - All 3 versions
- ►endojournals.org G Basta, AM Sironi, G Lazzerini, S Del Turco, E … - Journal of Clinical …, 2006 - Endocrine Soc Results: Plasma sRAGE was lower in diabetic patients than controls [141 (53–345) vs. 735
(519–1001) pg/ml, median (interquartile range), P < 0.0001], whereas CML levels were higher
in diabetic patients than controls [67.9 (46.0–84.7) vs. 43.4 (28.0–65.0) µg/ml, P < ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►endojournals.org SY Goh, ME Cooper - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Evidence Synthesis: In this review we report on how these AGEs may exert deleterious effects
in diabetes, as well as address current strategies to interrupt the formation or action of AGEs.
First, AGEs act directly to induce cross-linking of long-lived proteins such as collagen to ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►endojournals.org AM Vincent, L Perrone, KA Sullivan, C Backus, AM … - Endocrinology, 2007 - Endocrine Soc The receptor for advanced glycation end products (RAGE) may promote diabetic vascular and
renal disease through the activation of intracellular signaling pathways that promote oxidative
stress. Oxidative stress is a mediator of hyperglycemia-induced cell injury and a unifying ... Cited by 39 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org AS De Vriese, RG Tilton, S Mortier, NH … - Nephrology Dialysis …, 2006 - ERA-EDTA Background. Uraemia is associated with fibrosis of the peritoneal membrane, even prior to the
start of peritoneal dialysis. Increased carbonyl stress and the resultant formation of advanced
glycation end-products (AGEs) are potentially involved. The interaction of AGEs with their ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►biovita.fi [PDF] JM Forbes, K Fukami, ME Cooper… - Experimental and Clinical …, 2007 - thieme-connect.com Diabetic nephropathy (DN), the most common cause of end stage renal disease in developed
nations, is thought to result from interactions between metabolic and haemodynamic factors.
Specific metabolically driven, glucose dependent pathways are activated within diabetic ... Cited by 36 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org KM Myint, Y Yamamoto, T Doi, I Kato, A Harashima, H … - Diabetes, 2006 - Am Diabetes Assoc Diabetic nephropathy is a major microvascular complication in long-standing diabetic patients
who eventually undergo renal dialysis or transplantation. To prevent development of this disease
and to improve advanced kidney injury, effective therapies directed toward the key ... Cited by 35 - Related articles - BL Direct - All 6 versions
