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Scholar Results 1 - 10 of about 84 citing Guo: Peroxisome proliferator-activated receptor-γ ligands inhibit TGF-β1-induced fibronectin.... (0.12 sec) 

PPAR {gamma} agonists inhibit TGF-{beta} induced pulmonary myofibroblast differentiation and …

- physiology.org
HA Burgess, LE Daugherty, TH Thatcher, HF … - American Journal of Physiology- Lung Cellular and …, 2005 - Am Physiological Soc
Pulmonary fibrosis is a progressive life-threatening disease for which no
effective therapy exists. Myofibroblasts are one of the key effector cells in
pulmonary fibrosis and are the primary source of extracellular matrix ...
Cited by 94 - Related articles - All 4 versions

Peroxisome proliferator-activated receptor family and its relationship to renal complications …

- asnjournals.org
Y Guan - Journal of the American Society of Nephrology, 2004 - Am Soc Nephrol
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear
hormone receptor superfamily of ligand-activated transcription factors. Three
PPAR isoforms, designated PPAR , - / , and - , have been identified and ...
Cited by 89 - Related articles - BL Direct - All 5 versions

Protection of the kidney by thiazolidinediones: an assessment from bench to bedside


PA Sarafidis, GL Bakris - Kidney international, 2006 - nature.com
The global epidemic of diabetes mellitus has led to a continuous increase in the
prevalence of diabetic nephropathy over the past years. Thus, diabetic
nephropathy is currently the number one cause of end-stage renal disease in ...
Cited by 72 - Related articles - BL Direct - All 4 versions

The contribution of transforming growth factor-{beta} and epidermal growth factor signalling …


C Boxall, ST Holgate, DE Davies - European Respiratory Journal, 2006 - ersj.org.uk
The Brooke Laboratories, Division of Infection, Inflammation and Repair, School
of Medicine, Southampton General Hospital, Southampton, UK. ... Asthma is
increasing in prevalence in the developing world, affecting 10% of the ...
Cited by 72 - Related articles - BL Direct - All 7 versions

PPAR {gamma} agonists exert antifibrotic effects in renal tubular cells exposed to high …

- physiology.org [PDF] 
U Panchapakesan, S Sumual, CA Pollock, X … - American Journal of Physiology- Renal Physiology, 2005 - Am Physiological Soc
37 articles, 15 of which you can access free at: This article cites
http://ajprenal.physiology.org/cgi/content/full/289/5/F1153#BIBL ... 14 other
HighWire hosted articles, the first 5 are: This article has been cited by
Cited by 57 - Related articles - BL Direct - All 6 versions

Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy


N Sakai, T Wada, K Furuichi, Y Iwata, K … - American Journal of Kidney Diseases, 2005 - Elsevier
Background: The involvement of mitogen-activated protein kinase (MAPK) in human
diabetic nephropathy has not been fully investigated. Methods: The presence of
cells positive for the phosphorylated MAPK family (phosphorylated ...
Cited by 48 - Related articles - All 17 versions

Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of …

- asnjournals.org
Y Li, X Wen, BC Spataro, K Hu, C Dai, Y Liu - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol
Peroxisome proliferator–activated receptor- (PPAR- ) is a ligand-dependent
transcription factor that plays an important role in the regulation of insulin
sensitivity and lipid metabolism. Evidence shows that PPAR- agonists also ...
Cited by 41 - Related articles - BL Direct - All 8 versions

Estrogen and raloxifene, a selective estrogen receptor modulator, ameliorate renal damage …

- amjpathol.org
M Chin, M Isono, K Isshiki, S Araki, T … - American Journal of Pathology, 2005 - ASIP
Despite the potentially protective effects of estrogen on bone and
cardiovascular tissue as well as against kidney diseases, its effects on
diabetic nephropathy are unknown. Here, we examined the therapeutic ...
Cited by 32 - Related articles - All 6 versions

MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-β in rat mesangial cells


B Guo, K Inoki, M Isono, H Mori, K Kanasaki, … - Kidney international, 2005 - nature.com
Receptor-regulated Smads and/or mitogen-activated protein kinases (MAPKs) are
involved in transforming growth factor- (TGF- )–induced expression of various
genes, including plasminogen activator inhibitor-1 (PAI-1). Because the ...
Cited by 31 - Related articles - BL Direct - All 4 versions

HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent …


C Gaggioli, M Deckert, G Robert, P Abbe, M … - Oncogene, 2004 - nature.com
The matrix fibronectin protein is a multifunctional adhesive molecule that
promotes migration and invasiveness of many tumors including melanomas.
Increased fibronectin synthesis has been associated with the metastatic ...
Cited by 30 - Related articles - All 4 versions


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