- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM
are increasingly focused on disordered lipid metabolism. Here we review recent human ... Cited by 113 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Belfort, L Mandarino, S Kashyap, K Wirfel, T … - Diabetes, 2005 - Am Diabetes Assoc The dose-response relationship between elevated plasma free fatty acid (FFA) levels and impaired
insulin-mediated glucose disposal and insulin signaling was examined in 21 lean, healthy, normal
glucose-tolerant subjects. Following a 4-h saline or Liposyn infusion at 30 (n = 9), 60 (n = ... Cited by 88 - Related articles - All 5 versions
DK Richardson, S Kashyap, M Bajaj, K Cusi, SJ … - Journal of Biological …, 2005 - ASBMB Page 1. Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and
Increases Expression of Extracellular Matrix Genes in Human Skeletal Muscle Dawn K.
Richardson 1* , Sangeeta Kashyap 1* , Mandeep Bajaj 1 , Kenneth Cusi 1 , Steven J. ... Cited by 82 - Related articles - All 9 versions
- ►physiology.org LJC van Loon - Journal of Applied Physiology, 2004 - Am Physiological Soc Fat and carbohydrate are the principal substrates that fuel aerobic ATP synthesis in skeletal
muscle. Most endogenous fat is stored as triacylglycerol in subcutaneous and deep visceral
adipose tissue. Smaller quantities of triacylglycerol are deposited as lipid droplets inside ... Cited by 71 - Related articles - BL Direct - All 6 versions
- ►physiology.org JS Lee, SK Pinnamaneni, SJ Eo, IH Cho, … - Journal of applied …, 2006 - Am Physiological Soc Consumption of a Western diet rich in saturated fats is associated with obesity and insulin
resistance. In some insulin-resistant phenotypes this is associated with accumulation of skeletal
muscle fatty acids. We examined the effects of diets high in saturated fatty acids (Sat) or ... Cited by 60 - Related articles - BL Direct - All 9 versions
- ►jbc.org JA Chavez, WL Holland, J Bar, K Sandhoff, SA … - Journal of Biological …, 2005 - ASBMB Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation
of lipids in tissues not suited for fat storage, such as skeletal muscle and the liver. To elucidate
the mechanisms linking exogenous fats to the inhibition of insulin action, we evaluated ... Cited by 55 - Related articles - All 6 versions
- ►nih.gov AE Civitarese, B Ukropcova, S Carling, M Hulver, RA … - Cell metabolism, 2006 - Elsevier Insulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced
mitochondrial number and function. Here, we report that adiponectin signaling regulates mitochondrial
bioenergetics in skeletal muscle. Individuals with a family history of type 2 diabetes ... Cited by 56 - Related articles - All 15 versions
- ►nih.gov B Ukropcova, M McNeil, O Sereda, L de … - Journal of Clinical …, 2005 - Am Soc Clin Investig Metabolic flexibility of skeletal muscle, that is, the preference for fat oxidation (FOx) during fasting
and for carbohydrate oxidation in response to insulin, is decreased during insulin resistance.
The aim of this study was to test the hypothesis that the capacity of myotubes to oxidize fat ... Cited by 50 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org SA Summers, DH Nelson - Diabetes, 2005 - Am Diabetes Assoc Metabolic syndrome X and type 2 diabetes share many metabolic and morphological similarities
with Cushing's syndrome, a rare disorder caused by systemic glucocorticoid excess. Pathologies
frequently associated with these diseases include insulin resistance, atherosclerosis, ... Cited by 46 - Related articles - All 10 versions
HE Lebovitz - Diabetes, obesity & metabolism, 2006 - ccmjournal.org Evidence suggests that diabetes and cardiovascular disease (CVD) may share an underlying
cause(s), a theory known as the 'common soil' hypothesis. Insulin resistance is central both to
the progression from normal glucose tolerance to type 2 diabetes and to a constellation of ... Cited by 47 - Related articles - BL Direct - All 7 versions
