- ►aspetjournals.org PB Jacobson, TW von Geldern, L Ohman, M … - Journal of Pharmacology …, 2005 - ASPET Glucocorticoids amplify endogenous glucose production in type 2 diabetes by increasing hepatic
glucose output. Systemic glucocorticoid blockade lowers glucose levels in type 2 diabetes, but
with several adverse consequences. It has been proposed, but never demonstrated, that ... Cited by 30 - Related articles - BL Direct - All 5 versions
P Iozzo, R Lautamaki, F Geisler, KA Virtanen, V … - Diabetologia, 2004 - Springer Aims/hypothesis. We investigated the effect of elevat- ed circulating NEFA on insulin-mediated
hepatic glu- cose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male
subjects. Methods. Studies were performed using positron emission tomography (PET) ... Cited by 12 - Related articles - BL Direct - All 5 versions
MC Riddle - Endocrine Practice, 2006 - AACE Despite clear evidence that good glycemic control can reduce the microvascular complications
of diabetes, opti- mal control is seldom achieved or maintained in patients with type 2
diabetes. The currently recommended hemo- globin A1c (A1c) targets for treatment are ... Cited by 7 - Related articles - BL Direct - All 2 versions
- ►physiology.org SS Chen, CJ Torres-Sanchez, N Hosein, … - American Journal of …, 2005 - Am Physiological Soc In response to chronic (5 days) TPN, the liver becomes a major site of glucose disposal, removing
45% (4.5 mg·kg –1 ·min –1 ) of exogenous glucose. Moreover, 70% of glucose is not stored but
released as lactate. We aimed to determine in chronically catheterized conscious dogs ... Cited by 4 - Related articles - All 4 versions
D Dardevet, MC Moore, D Remond, CA … - Nutrition research …, 2007 - Cambridge Univ Press The liver plays a unique role in nutrient homeostasis. Its anatomical location makes it ideally
suited to control the systemic supply of absorbed nutrients, and it is the primary organ that can
both consume and produce substantial amounts of glucose. Moreover, it is the site of a ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►physiology.org C Everett-Grueter, DS Edgerton, EP … - American Journal of …, 2006 - Am Physiological Soc To determine the effect of nonesterified fatty acids (NEFA) on glucagon action, glucagon was
infused intraportally (1.65 ng·min –1 ·kg –1 ) for 3 h into 18-h-fasted, pancreatic-clamped conscious
dogs in the presence [NEFA + glucagon (GGN)] or absence (GGN) of peripheral Intralipid ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►physiology.org CA DiCostanzo, MC Moore, M Lautz, M … - American Journal of …, 2005 - Am Physiological Soc We examined the extent to which priming the liver with a pulse of Humulin or the insulin analog
hexyl-insulin monoconjugate 2 (HIM2) reduces postprandial hyperglycemia. Somatostatin (0.5
µg·kg –1 ·min –1 ) was given with basal intraportal insulin and glucagon for 4.5 h into ... Cited by 3 - Related articles - BL Direct - All 4 versions
K Cusi - Springer The epidemic of type 2 diabetes (T2DM) is a public health problem that threatens to spiral out
of control in the twenty-first century. Early intervention can greatly mitigate the serious socioeconomic
impact of the disease, driven largely by disabling microvascular complications and ... Cited by 2 - Related articles - All 2 versions
- ►physiology.org M Nishizawa, M Shiota, MC Moore, SM … - American Journal of …, 2008 - Am Physiological Soc We examined whether intraportal delivery of neuropeptide Y (NPY) affects glucose metabolism
in 42-h-fasted conscious dogs using arteriovenous difference methodology. The experimental
period was divided into three subperiods (P1, P2, and P3). During all subperiods, the ... Cited by 1 - Related articles - BL Direct - All 3 versions
- ►physiology.org MC Moore, CA DiCostanzo, MS Smith, B … - American Journal of …, 2008 - Am Physiological Soc Hepatic portal venous infusion of nitric oxide synthase (NOS) inhibitors causes muscle insulin
resistance, but the effects on hepatic glucose disposition are unknown. Conscious dogs underwent
a hyperinsulinemic (4-fold basal) hyperglycemic (hepatic glucose load 2-fold basal) ... Cited by 1 - Related articles - BL Direct - All 3 versions
