- ►physiology.org JJ Holst, J Gromada - American Journal of Physiology- …, 2004 - Am Physiological Soc The available evidence suggests that about two-thirds of the insulin response to an oral glucose
load is due to the potentiating effect of gut-derived incretin hormones. The strongest candidates
for the incretin effect are glucose-dependent insulinotropic polypeptide (GIP) and ... Cited by 180 - Related articles - BL Direct - All 4 versions
VO Nikolaev, M Bünemann, L Hein, A … - Journal of Biological …, 2004 - ASBMB The second messenger cAMP was discovered in the early 1950s, and since then its cellular
function and regulation have been gaining increased interest (1). cAMP is a ubiquitous second
messenger and regulates a wide variety of cellular events and biological processes from ... Cited by 139 - Related articles - BL Direct - All 6 versions
JL Bos - Trends in biochemical sciences, 2006 - Elsevier Epac1 and Epac2 are cAMP-dependent guanine-nucleotide-exchange factors for the small GTPases
Rap1 and Rap2, and are known to be important mediators of cAMP signaling. The recent determination
of the crystal structure of Epac2 has indicated a mechanism for the activation of the multi- ... Cited by 130 - Related articles - All 4 versions
- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal
epithelial endocrine L-cells by differential processing of proglucagon, the gene which is expressed
in these cells. The current knowledge regarding regulation of proglucagon gene ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org Y Li, X Cao, LX Li, PL Brubaker, H Edlund, DJ Drucker - Diabetes, 2005 - Am Diabetes Assoc Glucagon-like peptide-1 (GLP-1) regulates energy intake, gastrointestinal motility, and nutrient
disposal. The relative importance of the islet β-cell for GLP-1 actions remains unclear. We determined
the role of the islet β-cell and the pancreatic duodenal homeobox-1 (Pdx1) transcription ... Cited by 71 - Related articles - All 6 versions
S Park, X Dong, TL Fisher, S Dunn, AK Omer, G … - Journal of Biological …, 2006 - ASBMB The insulin receptor substrate 2 (Irs2) branch of the insulin/insulin-like growth factor-signaling
cascade prevents diabetes in mice because it promotes β cell replication, function, and
survival, especially during metabolic stress. Because exendin-4 (Ex4), a long acting ... Cited by 65 - Related articles - BL Direct - All 8 versions
GG Holz, G Kang, M Harbeck, MW Roe, OG … - The Journal of …, 2006 - Physiological Soc Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of
cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein kinase
A (PKA)-independent signal transduction properties of the second messenger cAMP. Two ... Cited by 65 - Related articles - BL Direct - All 32 versions
- ►ahajournals.org E Morel, A Marcantoni, M Gastineau, R Birkedal, F … - Circulation …, 2005 - Am Heart Assoc In the heart, cyclic adenosine 3',5'-monophosphate (cAMP) regulates many physiological processes
such as contractility and relaxation. Classically, these effects are attributed to activation of
hyperpolarization-activated cyclic nucleotide-gated channels and protein kinase A (PKA) ... Cited by 57 - Related articles - All 8 versions
- ►jimmunol.org DM Aronoff, C Canetti, CH Serezani, M Luo, … - The Journal of …, 2005 - Am Assoc Immnol Since its discovery, cAMP remains the archetypal "second messenger" responsible for directing
cellular responses to extracellular signals. In the alveolar macrophage (AM), 4 cAMP has largely
inhibitory effects on a variety of components of cell activation, including phagocytosis (1), ... Cited by 53 - Related articles - All 4 versions
G Kang, OG Chepurny, MJ Rindler, L Collis, … - The Journal of …, 2005 - Physiological Soc The blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1) stimulates cAMP
production, promotes Ca 2+ influx, and mobilizes an intracellular source of Ca 2+ in pancreatic
β cells. Here we provide evidence that these actions of GLP-1 are functionally related: ... Cited by 52 - Related articles - All 18 versions
