- ►nih.gov X Lin, A Taguchi, S Park, JA Kushner, F Li, Y … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The molecular link between obesity and β cell failure that causes diabetes is
difficult to establish. Here we show that a conditional knockout of insulin
receptor substrate 2 (Irs2) in mouse pancreas β cells and parts of the ... Cited by 115 - Related articles - BL Direct - All 11 versions
- ►shouxi.net S Park, X Dong, TL Fisher, S Dunn, AK Omer, … - Journal of Biological Chemistry, 2006 - ASBMB The insulin receptor substrate 2 (Irs2) branch of the insulin/insulin-like
growth factor-signaling cascade prevents diabetes in mice because it promotes β
cell replication, function, and survival, especially during metabolic ... Cited by 65 - Related articles - BL Direct - All 8 versions
- ►endocrinology-journals.org IK Lund, JA Hansen, HS Andersen, NPH Moller … - Journal of molecular endocrinology, 2005 - Soc Endocrinology Upon leptin binding, the leptin receptor is activated, leading to stimulation of
the JAK/STAT signal transduction cascade. The transient character of the
tyrosine phosphorylation of JAK2 and STAT3 suggests the involvement of ... Cited by 38 - Related articles - All 10 versions
MF White - Canadian journal of physiology and pharmacology, 2006 - article.pubs.nrc-cnrc.gc.ca Abstract: Diabetes mellitus is a complex disorder that arises from various
causes, including dysregulated glucose sensing and impaired insulin secretion
(maturity onset diabetes of youth, MODY), autoimmune-mediated b-cell ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►nih.gov X Dong, S Park, X Lin, K Copps, X Yi, MF … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF
receptor signals with heterologous pathways to coordinate growth and metabolism.
Since Irs2 is thought to be especially important in hepatic nutrient ... Cited by 36 - Related articles - BL Direct - All 12 versions
T Tiganis, AM Bennett - Biochemical Journal, 2007 - pubmedcentral.nih.gov It is now well established that the members of the PTP (protein tyrosine
phosphatase) superfamily play critical roles in fundamental biological
processes. Although there has been much progress in defining the function ... Cited by 32 - Related articles - BL Direct - All 6 versions
N Dubé, ML Tremblay - BBA-Proteins and Proteomics, 2005 - Elsevier As in other fields of biomedical research, the use of gene-targeted mice by
homologous recombination in embryonic stem cells has provided important findings
on the function of several members of the protein tyrosine phosphatase ... Cited by 29 - Related articles - All 3 versions
- ►jbc.org JA Kushner, L Simpson, LM Wartschow, S … - Journal of Biological Chemistry, 2005 - ASBMB The Irs2 branch of the insulin/insulin-like growth factor signaling cascade
activates the phosphatidylinositol 3-kinase Akt Foxo1 cascade in many tissues,
including hepatocytes and pancreatic -cells. The 3'-lipid phosphatase Pten ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►nih.gov AE Motter, N Gulbahce, E Almaas, AL … - Molecular Systems Biology, 2008 - nature.com Nature - the world's best science and medicine on your desktop.
Cited by 23 - Related articles - All 16 versions
B Xue, YB Kim, A Lee, E Toschi, S Bonner- … - Journal of Biological Chemistry, 2007 - ASBMB Mice heterozygous for insulin receptor (IR) and IR substrate (IRS)-1 deficiency
provide a model of polygenic type 2 diabetes in which early-onset, genetically
programmed insulin resistance leads to diabetes. Protein-tyrosine ... Cited by 13 - Related articles - All 7 versions
