- ►critcaremed.com P Reddy - Current opinion in hematology, 2004 - journals.lww.com Recent findings: Recent data from several laboratories have shed light on the structure of
IL-18; the signaling cascades that are initiated; and its role on modulating T cells, dendritic
cells, and natural killer cell function. Several new reports have expanded and delineated ... Cited by 82 - Related articles - BL Direct - All 9 versions
HE Thomas, W Irawaty, R Darwiche, TC Brodnicki, P … - Diabetes, 2004 - Am Diabetes Assoc Proinflammatory cytokines are believed to be important in pancreatic β-cell destruction in the
development of type 1 diabetes. They act by upregulation of genes including Fas and inducible
nitric oxide synthase (iNOS), which have both been shown to lead to β-cell death in vitro. ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►pnas.org S Kim, I Millet, HS Kim, JY Kim, MS Han, … - Proceedings of the …, 2007 - National Acad Sciences Whereas NF-κB has potent antiapoptotic function in most cell types, it was reported that in pancreatic
β cells it serves a proapoptotic function and may contribute to the pathogenesis of autoimmune
type 1 diabetes. To investigate the role of β cell NF-κB in autoimmune diabetes, we ... Cited by 31 - Related articles - BL Direct - All 10 versions
- ►cnr.it [PDF] D Boraschi, CA Dinarello - Eur Cytokine Netw, 2006 - john-libbey-eurotext.fr Immune activation is initiated in response to invading/stressful events of different origin (both
exogenous and endogenous). The innate immune system discriminates between self and
alien/abnormal molecular patterns and mounts the first set of inflammatory and defence ... Cited by 27 - Related articles - All 6 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
MS Lee, I Chang, S Kim - Molecular Genetics and Metabolism, 2004 - Elsevier While it is generally agreed that apoptosis of pancreatic β-cells is the most important and final
step in the progression of type 1 diabetes without which clinical diabetes does not develop, it
has not been elucidated which molecule(s) are the real culprit(s) in type 1 diabetes. ... Cited by 16 - Related articles - All 3 versions
- ►diabetesjournals.org S Kim, HS Kim, KW Chung, SH Oh, JW Yun, SH Im, MK … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—STAT1 −/− islet cells were resistant to death by interferon (IFN)-γ/tumor necrosis
factor (TNF)-α or IFN-γ/interleukin (IL)-1β combination. Cytochrome c translocation by
IFN-γ/TNF-α was abrogated in STAT1 −/− islet cells. The induction of X-linked inhibitor of ... Cited by 8 - Related articles - BL Direct - All 6 versions
M Jelusic, IK Lukic, D Batinic - Drug News Perspect, 2007 - journals.prous.com Interleukin (IL)-18 is an important regulator of both innate and acquired immune responses. It
is upregulated in several human autoimmune and inflammatory diseases, and, therefore, might
represent a novel therapeutic target. This review highlights the biology of IL-18, its central ... Cited by 2 - Related articles - All 4 versions
