- ►sciencesignaling.org CJ Rhodes - Science Signaling, 2005 - sciencesignaling.org Abstract: In type 2 diabetes, the ß cells of the pancreas fail to produce
enough insulin to meet the body's demand, in part because of an acquired
decrease in ß-cell mass. In adults, pancreatic ß-cell mass is controlled ... Cited by 287 - Related articles - All 13 versions
K AD'Amour, AG Bang, S Eliazer, OG Kelly, … - Nature - med.upenn.edu Of paramount importance for the development of cell therapies to treat diabetes
is the production of sufficient numbers of pancreatic endocrine cells that
function similarly to primary islets. We have developed a differentiation ... Cited by 277 - Related articles - View as HTML - BL Direct - All 17 versions
S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 175 - Related articles - All 3 versions
- ►publichealth.ru [PDF] D Daneman - The Lancet, 2006 - Elsevier Type 1 diabetes accounts for only about 5–10% of all cases of diabetes;
however, its incidence continues to increase worldwide and it has serious
short-term and long-term implications. The disorder has a strong genetic ... Cited by 126 - Related articles - All 27 versions
- ►alphamedpress.org Y Shi, L Hou, F Tang, W Jiang, P Wang, M … - Stem Cells, 2005 - AlphaMed Press Experimental induction of embryonic stem cells (ESCs) to become pancreatic ß
cells can potentially provide ample resource for cell transplantation therapy of
type I diabetes mellitus. Most of the previously reported induction ... Cited by 96 - Related articles - All 6 versions
- ►diabetesjournals.org GKC Brolén, N Heins, J Edsbagge, H Semb - Diabetes, 2005 - Am Diabetes Assoc The recent success in restoring normoglycemia in type 1 diabetes by islet cell
transplantation indicates that cell replacement therapy of this severe disease
is achievable. However, the severe lack of donor islets has increased the ... Cited by 81 - Related articles - BL Direct - All 6 versions
P Blyszczuk, C Asbrand, A Rozzo, G Kania, … - Int J Dev Biol, 2004 - ijdb.ehu.es ABSTRACT We present a new strategy for the differentiation of embryonic stem
(ES) cells into insulin-producing cells via a multi-step process without
selection and induction of nestin-positive cells. During ES cell ... Cited by 66 - Related articles - View as HTML - All 6 versions
A Lechner, AL Nolan, RA Blacken, JF … - Biochemical and Biophysical Research …, 2005 - Elsevier Cellular replacement therapy holds promise for the treatment of diabetes
mellitus but donor tissue is severely limited. Therefore, we investigated
whether insulin-secreting cells could be differentiated in vitro from a ... Cited by 64 - Related articles - All 4 versions
- ►alphamedpress.org P Vaca, F Martin, JM Vegara-Meseguer, JM … - Stem Cells, 2006 - AlphaMed Press Cell signals produced during pancreas embryogenesis regulate pancreatic
differentiation. We show that the developing pancreas releases soluble factors
responsible for in vitro endocrine pancreatic differentiation from ... Cited by 53 - Related articles - BL Direct - All 8 versions
JH Shim, SE Kim, DH Woo, SK Kim, CH Oh, R … - Diabetologia, 2007 - Springer Page 1. ARTICLE Directed differentiation of human embryonic stem cells towards
a pancreatic cell fate JH Shim & SE Kim & DH Woo & SK Kim & ... Cited by 48 - Related articles - BL Direct - All 5 versions
