- ►aspetjournals.org MW Fariss, CB Chan, M Patel, B Van Houten, … - Molecular interventions, 2005 - ASPET Oxidative stress and mitochondrial oxidative damage have been implicated in the
etiology of numerous common diseases. The critical mitochondrial events
responsible for oxidative stress–mediated cell death (toxic oxidative ... Cited by 69 - Related articles - All 2 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►nutrition.org V Poitout, D Hagman, R Stein, I Artner, RP … - Journal of Nutrition, 2006 - Am Soc Nutrition The insulin gene is expressed almost exclusively in pancreatic ß-cells.
Metabolic regulation of insulin gene expression enables the ß-cell to maintain
adequate stores of intracellular insulin to sustain the secretory demand. ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►nih.gov DK Hagman, LB Hays, SD Parazzoli, V … - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to
both defective insulin secretion from the pancreatic beta cell and peripheral
insulin resistance in type 2 diabetes. Previously, we have shown that ... Cited by 42 - Related articles - BL Direct - All 10 versions
- ►physiology.org K Fujiwara, F Maekawa, T Yada - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc It has long been thought that long-chain free fatty acids (FFAs) stimulate
insulin secretion via mechanisms involving their metabolism in pancreatic
-cells. Recently, it was reported that FFAs function as endogenous ligands ... Cited by 40 - Related articles - BL Direct - All 3 versions
JH Moffitt, BA Fielding, R Evershed, R Berstan … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Long-term exposure of beta cells to lipids,
particularly saturated fatty acids in vitro, results in cellular dysfunction and
apoptosis (lipotoxicity); this could contribute to obesity-related ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►endojournals.org WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc Obesity and dyslipidemia are risk factors for metabolic disorders including
diabetes and cardiovascular disease. Sphingolipids such as ceramide and
glucosylceramides, while being a relatively minor component of the lipid ... Cited by 29 - Related articles - All 7 versions
- ►diabetesjournals.org AI Oprescu, G Bikopoulos, A Naassan, EM … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Forty-eight–hour infusion of oleate decreased the insulin and
C-peptide responses to a hyperglycemic clamp (P < 0.01), an effect prevented by
coinfusion of the antioxidants N-acetylcysteine (NAC) and taurine. Similar ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org SJ Persaud, D Muller, VD Belin, I Kitsou- … - Diabetes, 2007 - Am Diabetes Assoc The roles played by arachidonic acid and its cyclooxygenase (COX)-generated and
lipoxygenase (LOX)-generated metabolites have been studied using rodent islets
and insulin-secreting cell lines, but very little is known about COX and ... Cited by 12 - Related articles - BL Direct - All 5 versions
KJ Chang-Chen, R Mullur, E Bernal-Mizrachi - Reviews in Endocrine & Metabolic Disorders, 2008 - Springer Abstract Type 2 diabetes mellitus is a complex disease characterized by b-cell
failure in the setting of insulin resistance. In early stages of the disease,
pancreatic b-cells adapt to insulin resistance by increasing mass and ... Cited by 11 - Related articles - All 2 versions
