- ►endojournals.org R Muniyappa, M Montagnani, KK Koh, MJ Quon - Endocrine reviews, 2007 - Endocrine Soc Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent
augmentation of glucose disposal in classical insulin target tissues (e.g., skeletal muscle). ... Cited by 101 - Related articles - BL Direct - All 5 versions
IL Williams, PJ Chowienczyk, SB Wheatcroft, AG Patel, … - Obesity surgery, 2005 - Springer Background: Obesity is a major risk factor for the development of endothelial dysfunction. We
explored the effect of different degrees of body mass on endothelial function, lipids, systemic
inflammation and glucose homeostasis and the effect of surgically- induced weight loss ... Cited by 38 - Related articles - BL Direct - All 5 versions
BT Noronha, JM Li, SB Wheatcroft, AM Shah, MT … - Diabetes, 2005 - Am Diabetes Assoc Previous studies have suggested an involvement of inducible nitric oxide synthase (iNOS) in
obesity, but the relation, if any, between this and mechanisms underlying endothelial dysfunction
in obesity is unknown. We studied mice fed an obesogenic high-fat or standard diet for up ... Cited by 31 - Related articles - All 5 versions
C Murphy, GS Kanaganayagam, B Jiang, PJ … - … , and vascular biology, 2007 - Am Heart Assoc Methods and Results— 24 South Asian and 25 Caucasian healthy age-matched nonsmoking
men were studied. Vascular function was assessed by flow-mediated and GTN brachial artery
dilatation and blood flow responses to infusion of ACh, SNP, and L-NMMA. EPC number ... Cited by 29 - Related articles - All 8 versions
SB Wheatcroft, MT Kearney, AM Shah, VA Ezzat, JR … - Diabetes, 2007 - Am Diabetes Assoc Proliferation of adipocyte precursors and their differentiation into mature adipocytes contributes
to the development of obesity in mammals. IGF-I is a potent mitogen and important stimulus for
adipocyte differentiation. The biological actions of IGFs are closely regulated by a family ... Cited by 17 - Related articles - BL Direct - All 12 versions
N Wiernsperger, P Nivoit, LGK De Aguiar, E … - …, 2007 - informahealthcare.com The present review, to the authors' knowledge, is the first to specifically address the relationships
between microcirculation and metabolic syndrome, a cluster of metabolic and cardiovascular
modifications highly prevalent in the general population. Its close link to overweight and ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►sherbornegibbs.com [PDF] RM Cubbon, A Rajwani, SB Wheatcroft - Diabetes & Vascular Disease …, 2007 - dvr.sagepub.com Abstract T he structural and functional integrity of the vascular endothelium plays a critical role
in vascular homeo- stasis. Insulin resistance, an important risk factor for cardiovascular
disease, is thought to promote athero- sclerosis through a reciprocal relationship with ... Cited by 17 - Related articles - BL Direct - All 8 versions
- ►physiology.org ER Duncan, SJ Walker, VA Ezzat, SB … - American Journal of …, 2007 - Am Physiological Soc Insulin resistance is well established as an independent risk factor for the development of type
2 diabetes and cardiovascular atherosclerosis. Most studies have examined atherogenesis in
models of severe insulin resistance or diabetes. However, by the time of diagnosis, ... Cited by 13 - Related articles - BL Direct - All 3 versions
MT Kearney, ER Duncan, M Kahn, SB … - Experimental …, 2008 - Physiological Soc Type 2 diabetes and obesity are major risk factors for the development of cardiovascular
atherosclerosis. Resistance to the metabolic effects of insulin on its traditional target tissues
(muscle, liver and adipose tissue) is a central pathogenic feature of these disorders. ... Cited by 10 - Related articles - BL Direct - All 11 versions
ER Duncan, PA Crossey, S Walker, N Anilkumar, L … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—ESMIRO mice had preserved glucose homeostasis and were normotensive. They
had significant endothelial dysfunction as evidenced by blunted aortic vasorelaxant responses
to acetylcholine (ACh) and calcium ionophore. Furthermore, the vascular action of insulin ... Cited by 8 - Related articles - All 3 versions
