- ►shouxi.net AP Babenko, M Polak, H Cave, K Busiah, P … - The New England journal of medicine, 2006 - nejm.highwire.org Background The ATP-sensitive potassium (K ATP ) channel, composed of the
beta-cell proteins sulfonylurea receptor (SUR1) and inward-rectifying potassium
channel subunit Kir6.2, is a key regulator of insulin release. It is ... Cited by 155 - Related articles - BL Direct - All 12 versions
- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) in response to
metabolically generated ATP or binding of sulfonylurea drugs stimulates insulin
release from pancreatic β-cells. Heterozygous gain-of-function mutations ... Cited by 138 - Related articles - BL Direct - All 10 versions
- ►shouxi.net ER Pearson, I Flechtner, PR Njolstad, MT … - New England Journal of Medicine, 2006 - content.nejm.org Background Heterozygous activating mutations in KCNJ11, encoding the Kir6.2
subunit of the ATP-sensitive potassium (K ATP ) channel, cause 30 to 58 percent
of cases of diabetes diagnosed in patients under six months of age. ... Cited by 127 - Related articles - BL Direct - All 13 versions
- ►nih.gov P Proks, JF Antcliff, J Lippiat, AL Gloyn, AT … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Inwardly rectifying potassium channels (Kir channels) control cell membrane K +
fluxes and electrical signaling in diverse cell types. Heterozygous mutations in
the human Kir6.2 gene (KCNJ11), the pore-forming subunit of the ... Cited by 115 - Related articles - All 11 versions
JF Antcliff, S Haider, P Proks, MSP Sansom, … - The EMBO Journal, 2005 - pubmedcentral.nih.gov ATP-sensitive potassium (K ATP ) channels couple cell metabolism to electrical
activity by regulating K flux across the plasma membrane. Channel closure is
mediated by ATP, which binds to the pore-forming subunit (Kir6.2). Here we ... Cited by 93 - Related articles - All 10 versions
- ►oxfordjournals.org P Proks, AL Arnold, J Bruining, C Girard, SE … - Human molecular genetics, 2006 - Oxford Univ Press Neonatal diabetes is a genetically heterogeneous disorder with nine different
genetic aetiologies reported to date. Heterozygous activating mutations in the
KCNJ11 gene encoding Kir6.2, the pore-forming subunit of the ATP-sensitive ... Cited by 76 - Related articles - BL Direct - All 9 versions
SE Flanagan, EL Edghill, AL Gloyn, S Ellard, … - Diabetologia, 2006 - Springer Mutations in KCNJ11, which encodes Kir6.2, are a common cause ... Received: 3
November 2005 / Accepted: 28 February 2006 / Published online: 12 April 2006 #
Springer-Verlag 2006 ... Abstract Aims/hypothesis: Heterozygous ... Cited by 74 - Related articles - BL Direct - All 4 versions
- ►jbc.org A Miura, K Yamagata, M Kakei, H Hatakeyama … - Journal of Biological Chemistry, 2006 - ASBMB Mutations in the hepatocyte nuclear factor (HNF)-4 gene cause a form of
maturity-onset diabetes of the young (MODY1) that is characterized by impairment
of glucose-stimulated insulin secretion by pancreatic -cells. HNF-4 , a ... Cited by 51 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the
pancreatic β-cell, thereby coupling metabolism to electrical activity and
ultimately to insulin secretion. When K ATP channels open, β-cells ... Cited by 43 - Related articles - BL Direct - All 5 versions
