- ►cell.com S Wullschleger, R Loewith, MN Hall - Cell, 2006 - Elsevier The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell
growth and metabolism in response to environmental cues. Here, highlighting
contributions from studies in model organisms, we review mammalian TOR ... Cited by 795 - Related articles - All 30 versions
CK Tsang, H Qi, LF Liu, XFS Zheng - Drug discovery today, 2007 - Elsevier The macrolide rapamycin is used clinically to treat graft rejection and
restenosis. Mammalian target of rapamycin (mTOR) is a central controller of
cellular and organism growth that integrates nutrient and hormonal signals, ... Cited by 61 - Related articles - All 5 versions
- ►nih.gov O Le Bacquer, E Petroulakis, S Paglialunga, … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The most common pathology associated with obesity is insulin resistance, which
results in the onset of type 2 diabetes mellitus. Several studies have
implicated the mammalian target of rapamycin (mTOR) signaling pathway in ... Cited by 44 - Related articles - BL Direct - All 8 versions
GA Soliman - Current opinion in lipidology, 2005 - journals.lww.com Purpose of review The mammalian target of rapamycin (mTOR) is a key integrator
of signals from nutrients, energy and insulin. TOR is a protein kinase
originally identified in yeast by the genetic selection of ... Cited by 29 - Related articles - All 3 versions
- ►diabetesjournals.org M Krebs, B Brunmair, A Brehm, M Artwohl, J … - Diabetes, 2007 - Am Diabetes Assoc Type 2 diabetes is closely linked to obesity and insulin resistance (1–3). In
addition to polygenic predisposition, environmental factors including quality
and quantity of food supply, dietary behavior, and physical activity are of ... Cited by 26 - Related articles - BL Direct - All 5 versions
M Roth, JL Black - Current drug targets, 2006 - ingentaconnect.com Abstract: The essential features of persistent severe asthma include structural
changes in the airway wall (remodelling). It is not known whether these are the
sequelae of chronic inflammation or indeed its initiators. Several ... Cited by 29 - Related articles - BL Direct - All 3 versions
- ►aacrjournals.org KL Bennett, B Hackanson, LT Smith, CD … - Cancer Research, 2007 - AACR Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in
the world (1). It is primarily caused by exposure to alcohol and tobacco
products, which influence major pathways of cell proliferation (2). Surgery ... Cited by 23 - Related articles - BL Direct - All 3 versions
T Shavlakadze, M Grounds - Bioessays, 2006 - school.anhb.uwa.edu.au Summary Extreme loss of skeletal muscle mass (atrophy) occurs in human muscles
that are not used. In striking contrast, skeletal muscles do not rapidly waste
away in hibernating mammals such as bears, or aestivating frogs, subjected ... Cited by 17 - Related articles - View as HTML - BL Direct - All 5 versions
NJ Linford, RP Beyer, K Gollahon, RA Krajcik … - Journal of Anatomy - interscience.wiley.com Sustained caloric restriction (CR) extends lifespan in animal models but the
mechanism and primary tissue target(s) have not been identified. Gene expression
changes with aging and CR were examined in both heart and white adipose ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►drugdiscoverytoday.com [PDF] MV Blagosklonny - Drug discovery today, 2007 - Elsevier Numerous mutations increase lifespan in diverse organisms from worms to mammals.
Most genes that affect longevity encode components of the target of rapamycin
(TOR) pathway, thus revealing potential targets for pharmacological ... Cited by 12 - Related articles - All 8 versions
