- ►nih.gov MA Herman, BB Kahn - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The prevalence of obesity and type 2 diabetes continues to increase at alarming rates (1). Type
2 diabetes is a prototypic complex, polygenic disease with a strong heritable component, which
is also heavily influenced by environmental factors — especially diet and physical activity. ... Cited by 58 - Related articles - BL Direct - All 9 versions
- ►oxfordjournals.org L Visser, CJ Zuurbier, FJ Hoek, BC … - British Journal of …, 2005 - British Jrnl Anaesthesia Methods. Data obtained in 21 non-diabetic patients with normal left ventricular function scheduled
for elective coronary artery surgery, who were randomly allocated to a control or GIK group, were
analysed. In GIK patients, regular insulin was infused at a fixed rate of 0.1 IU kg –1 h –1 . ... Cited by 56 - Related articles - BL Direct - All 12 versions
D Burdakov, SM Luckman, A … - … Transactions of the …, 2005 - rstb.royalsocietypublishing.org Specialized subgroups of hypothalamic neurons exhibit specific excitatory or inhibitory electrical
responses to changes in extracellular levels of glucose. Glucose-excited neurons were traditionally
assumed to employ a 'β-cell' glucose-sensing strategy, where glucose elevates cytosolic ... Cited by 33 - Related articles - BL Direct - All 13 versions
PD Mountjoy, SJ Bailey, GA Rutter - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Changes in the activity of glucose-excited and glucose-inhibited neurons
within the basomedial hypothalamus are key to the central regulation of satiety. However, the
molecular mechanisms through which these cells respond to extracellular stimuli remain ... Cited by 25 - Related articles - BL Direct - All 6 versions
CV Mobbs, F Isoda, H Makimura, J Mastaitis, T Mizuno, … - Physiology & behavior, 2005 - Elsevier Since nutrition-sensitive feedback signals normally act to maintain relatively stable levels of both
available and stored nutritional resources, failure in one or more of these feedback signals could
plausibly lead to obese phenotypes. The glucostatic hypothesis in its original form posited ... Cited by 22 - Related articles - All 4 versions
N Marty, M Dallaporta, B Thorens - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov Neuronal circuits in the central nervous system play a critical role in orchestrating the control
of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected
by several glucose-sensing units that are located at different anatomical sites and ... Cited by 22 - Related articles - BL Direct - All 4 versions
X Fioramonti, S Contie, Z Song, VH Routh, A Lorsignol, … - Diabetes, 2007 - Am Diabetes Assoc Four types of responses to glucose changes have been described in the arcuate nucleus
(ARC): excitation or inhibition by low glucose concentrations <5 mmol/l (glucose-excited and
-inhibited neurons) and by high glucose concentrations >5 mmol/l (high glucose–excited ... Cited by 22 - Related articles - BL Direct - All 5 versions
L Pénicaud, C Leloup, X Fioramonti, A … - Current Opinion in …, 2006 - journals.lww.com Purpose of review Brain nutrient sensing allows a fine regulation of different physiological
functions, such as food intake and blood glucose, related to energy homeostasis. Glucose sensing
is the most studied function and a parallel has been made between the cellular ... Cited by 21 - Related articles - BL Direct - All 5 versions
C Leloup, C Magnan, A Benani, E Bonnet, T Alquier, G … - Diabetes, 2006 - Am Diabetes Assoc The physiological signaling mechanisms that link glucose sensing to the electrical activity in
metabolism-regulating hypothalamus are still controversial. Although ATP production was considered
the main metabolic signal, recent studies show that the glucose-stimulated signaling in ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►cjb.net X Ma, L Zubcevic, JC Bruning, FM Ashcroft, D … - Journal of …, 2007 - neuro.cjb.net Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus (ARC) suppress
appetite, and lack of POMC-derived peptides or electrical silencing of POMC neurons causes
obesity. ARC POMC neurons are surrounded by nerve terminals containing the ... Cited by 15 - Related articles - All 4 versions
