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Scholar Results 1 - 10 of about 26 citing Blüher: Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight,.... (0.10 sec) 

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK


MJ Watt, N Dzamko, WG Thomas, S Rose-John, … - Nature medicine, 2006 - nature.com
Cited by 77 - Related articles - BL Direct - All 8 versions

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating …

- endojournals.org
MJ Watt, A Hevener, GI Lancaster, MA … - Endocrinology, 2006 - Endocrine Soc
Ciliary neurotrophic factor (CNTF) is a member of the gp130 receptor cytokine
family recently identified as an antiobesity agent in rodents and humans by
mechanisms that remain unclear. We investigated the impact of acute CNTF ...
Cited by 36 - Related articles - All 5 versions

Regulation of adiponectin and its receptors in response to development of diet-induced …

- physiology.org
JW Bullen Jr, S Bluher, T Kelesidis, CS … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc
Adiponectin and its receptors play an important role in energy homeostasis and
insulin resistance, but their regulation remains to be fully elucidated. We
hypothesized that high-fat diet would decrease adiponectin but increase ...
Cited by 34 - Related articles - BL Direct - All 5 versions

The hypothalamus and obesity


PJ King - Current Drug Targets, 2005 - ingentaconnect.com
Abstract: Obesity, a condition already at epidemic proportions in the developed
world, is largely attributable to an indulgent lifestyle. Biologically we feel
hunger more acutely than feeling 'full-up' (satiety). The discovery over a ...
Cited by 29 - Related articles - All 3 versions

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin- …

- endojournals.org
GR Steinberg, MJ Watt, BC Fam, J Proietto, … - Endocrinology, 2006 - Endocrine Soc
We examined the actions of a second-generation ciliary neurotrophic factor
analog (CNTF Ax15 ) on AMP-activated protein kinase (AMPK), a known regulator of
food intake. Unlike leptin CNTF Ax15 has been shown to reduce food intake ...
Cited by 30 - Related articles - BL Direct - All 6 versions

gp130 receptor ligands as potential therapeutic targets for obesity

- nih.gov
MA Febbraio - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig
Obesity and its related cluster of pathophysiologic conditions including insulin
resistance, glucose intolerance, dyslipidemia, and hypertension are recognized
as growing threats to world health. It is now estimated that 10% of the ...
Cited by 26 - Related articles - BL Direct - All 7 versions

Investigational therapies in the treatment of obesity


MC Mancini, A Halpern - Expert Opin. Investig. Drugs, 2006 - informahealthcare.com
Obesity is a major public health concern and environmental factors are involved
in its development. The hypothalamus is a primary site for the integration of
signals for the regulation of energy homeostasis. Dysregulation of these ...
Cited by 11 - Related articles - BL Direct - All 5 versions

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet- …

- cjb.net
D Cota, EK Matter, SC Woods, RJ Seeley - Journal of Neuroscience, 2008 - neuro.cjb.net
The mammalian target of rapamycin (mTOR) kinase is a key regulator of several
cellular functions, including cell growth and differentiation. Because
hypothalamic mTOR complex 1 (mTORC1) signaling has been implicated as a ...
Cited by 11 - Related articles - All 6 versions

[PDF] Thermogenic and metabolic antiobesity drugs: rationale and opportunities


JC Clapham, JR Arch - Diabetes Obes Metab, 2007 - ephedraguide.com
Antiobesity drugs that target peripheral metabolism may avoid some of the
problems that have been encountered with centrally acting anorectic drugs.
Moreover, if they cause weight loss by increasing fat oxidation, they not ...
Cited by 9 - Related articles - View as HTML - All 4 versions

Functional gene expression differences between inbred alcohol-preferring and–non-preferring …

- nih.gov [PDF] 
MW Kimpel, WN Strother, JN McClintick, LG … - Alcohol, 2007 - Elsevier
The objective of this study was to determine if there are innate differences in
gene expression in selected CNS regions between inbred alcohol-preferring (iP)
and –non-preferring (iNP) rats. Gene expression was determined in the ...
Cited by 10 - Related articles - All 6 versions


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