- ►diabetesjournals.org GS Hotamisligil - Diabetes, 2005 - Am Diabetes Assoc Metabolic and immune systems are the most fundamental requirements for survival, and many
metabolic and immune response pathways or nutrient- and pathogen-sensing systems have
been evolutionarily highly conserved. Consequently, metabolic and immune pathways ... Cited by 106 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] EC Lewis, L Shapiro, OJ Bowers, CA … - Proceedings of the …, 2005 - National Acad Sciences Islet transplantation for type 1 diabetic patients shows promising results with the use of nondiabetogenic
immunosuppressive therapy. However, in addition to compromising the immune system of transplant
recipients, long-term studies demonstrate that islet viability is impaired. Here, we ... Cited by 41 - Related articles - BL Direct - All 7 versions
H Noguchi, Y Nakai, S Matsumoto, M … - American Journal of …, 2005 - ccmjournal.org Although application of the Edmonton protocol has markedly improved outcomes for pancreatic
islet transplantation, the insulin independence rate after islet transplantation from one donor
pancreas has proven to remain low. During the isolation process and subsequent clinical ... Cited by 37 - Related articles - All 7 versions
SA Ahmad, CJ Wray, HR Rilo, KA Choe, A Gelrud, J … - Current Problems in …, 2006 - Elsevier Chronic pancreatitis is an ongoing inflammatory disorder characterized by irreversible destruction
of the pancreas associated with disabling chronic pain and permanent loss of exocrine and endocrine
function. The apparent incidence of chronic pancreatitis has nearly quadrupled in the past ... Cited by 26 - Related articles - All 4 versions
AN Balamurugan, J He, F Guo, DB Stolz, … - American Journal of …, 2005 - interscience.wiley.com The isolation process exposes human pancreatic islets to exogenous isolation enzymes. Exposure
to these enzymes, as a result of intraductal injection in the pancreas or simple contact of islets
with enzyme components, causes internalization into the islet cells of enzymes and their ... Cited by 20 - Related articles - BL Direct - All 4 versions
H Noguchi, Y Nakai, M Ueda, Y Masui, S Futaki, N … - Diabetologia, 2007 - Springer Page 1. ARTICLE Activation of c-Jun NH 2 -terminal kinase (JNK) pathway during islet
transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor H. Noguchi
& Y. Nakai & M. Ueda & Y. Masui & S. Futaki & N. Kobayashi & S. Hayashi & S. Matsumoto ... Cited by 15 - Related articles - BL Direct - All 6 versions
J Avila, B Barbaro, A Gangemi, T Romagnoli, J … - American Journal of …, 2005 - ccmjournal.org Oxidative stress during islet isolation induces a cascade of events injuring islets and hampering
islet engraftment. This study evaluated islet isolation and transplantation outcomes after
intra-ductal glutamine administration. Human pancreata deemed unsuitable for pancreas ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►diabetesresearch.org [PDF] A Fornoni, A Pileggi, RD Molano, NY Sanabria, T … - Diabetologia, 2008 - Springer Page 1. ARTICLE Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell
mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3)
phosphorylation A. Fornoni & A. Pileggi & RD Molano & NY Sanabria & ... Cited by 15 - Related articles - BL Direct - All 3 versions
S Abdelli, A Abderrahmani, BJ Hering, JS Beckmann, C … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis The protocols used for the preparation of human pancreatic islets immediately
induce a sustained and massive activation of the c-Jun-N-terminal kinase (JNK). JNK, which
participates in apoptosis of insulin-secreting cells, is activated by mechanical stresses, as ... Cited by 14 - Related articles - BL Direct - All 4 versions
AK Cardozo, V Buchillier, M Mathieu, J Chen, F Ortis, L … - BBA-Biomembranes, 2007 - Elsevier We have explored the threshold of tolerance of three unrelated cell types to treatments with potential
cytoprotective peptides bound to Tat 48–57 and Antp 43–58 cell-permeable peptide carriers.
Both Tat 48–57 and Antp 43–58 are well known for their good efficacy at crossing ... Cited by 13 - Related articles - All 3 versions
