D Jay, H Hitomi, KK Griendling - Free Radical Biology and Medicine, 2006 - Elsevier Diabetes diagnoses are increasing at an alarming rate worldwide. The majority of
diabetes-related deaths arise from cardiovascular complications such as
myocardial infarction, stroke, and peripheral vascular disease. Oxidative ... Cited by 110 - Related articles - All 4 versions
- ►endojournals.org SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - Endocrine Soc Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The
reduction of glucose by the AR-catalyzed polyol pathway has been linked to the
development of secondary diabetic complications. Although treatment with AR ... Cited by 97 - Related articles - All 6 versions
KV Ramana, B Friedrich, R Tammali, MB West, … - Diabetes, 2005 - Am Diabetes Assoc Activation of protein kinase C (PKC) has been linked to the development of
secondary diabetes complications. However, the underlying molecular mechanisms
remain unclear. We examined the contribution of aldose reductase, which ... Cited by 47 - Related articles - All 5 versions
T Mazzone, A Chait, J Plutzky - The Lancet, 2008 - Elsevier Individuals with type 2 diabetes mellitus have increased cardiovascular disease
risk compared with those without diabetes. Treatment of the residual risk, other
than blood pressure and LDL-cholesterol control, remains important as the ... Cited by 37 - Related articles - All 11 versions
KV Ramana, A Bhatnagar, S Srivastava, UC … - Journal of Biological Chemistry, 2006 - ASBMB Products of lipid peroxidation such as 4-hydroxy-trans-2-nonenal (HNE) trigger
multiple signaling cascades that variably affect cell growth, differentiation,
and apoptosis. Because glutathiolation is a significant metabolic fate of ... Cited by 37 - Related articles - BL Direct - All 7 versions
TS Kern - Exp Diabetes Res, 2007 - hindawi.com Diabetes causes metabolic and physiologic abnormalities in the retina, and these
changes suggest a role for inflammation in the development of diabetic
retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, ... Cited by 34 - Related articles - View as HTML - All 12 versions
- ►ahajournals.org [PDF] KV Ramana, MS Willis, MD White, JW Horton, … - Circulation, 2006 - Am Heart Assoc Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams &
Wilkins, a division of Wolters ... Inflammation in Mice Is Prevented by Aldose Cited by 30 - Related articles - All 11 versions
- ►jbc.org K Kaiserova, S Srivastava, JD Hoetker, SO … - Journal of Biological Chemistry, 2006 - ASBMB Aldose reductase (AR) reduces cytotoxic aldehydes and glutathione conjugates of
aldehydes derived from lipid peroxidation. Its inhibition has been shown to
increase oxidative injury and abolish the late phase of ischemic ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►jbc.org KV Ramana, AA Fadl, R Tammali, A Reddy, … - Journal of Biological Chemistry, 2006 - ASBMB Abnormal production of inflammatory cytokines and chemokines is a key feature of
bacterial endotoxin, lipopolysaccharide (LPS)-induced inflammation, and
cytotoxicity; however, the mechanisms regulating production of inflammatory ... Cited by 18 - Related articles - All 7 versions
