- ►diabetesjournals.org G Wolf, S Chen, FN Ziyadeh - Diabetes, 2005 - Am Diabetes Assoc Nephropathy is a major complication of diabetes. Alterations of mesangial cells have traditionally
been the focus of research in deciphering molecular mechanisms of diabetic nephropathy. Injury
of podocytes, if recognized at all, has been considered a late consequence caused by ... Cited by 188 - Related articles - All 9 versions
G Wolf - Kidney international, 2006 - nature.com Glomerulosclerosis, interstitial fibrosis, and tubular atrophy occur with end-stage kidney
failure, irrespective of the primary etiology. The transforming growth factor- (TGF- ) is a key factor
in these alterations either directly, by stimulating synthesis of extracellular matrix ... Cited by 67 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org SH Sung, FN Ziyadeh, A Wang, PE Pyagay, … - Journal of the American …, 2006 - Am Soc Nephrol For investigation of how the vascular endothelial growth factor (VEGF) system participates in
the pathogenesis of diabetic kidney disease, type 2 diabetic db/db and control db/m mice were
treated intraperitoneally with vehicle or 2 mg/kg of a pan-VEGF receptor tyrosine kinase ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org S Chen, JS Lee, MC Iglesias-De La Cruz, A Wang … - Nephrology Dialysis …, 2005 - ERA-EDTA Results. AngII 10 –10 M was found to stimulate the production of 3(IV) collagen significantly in
as short a time as 3 h. The expression of 3(IV) collagen was influenced by the TGF-ß system,
but AngII did not increase the podocyte's production of TGF-ß1 ligand; rather, it increased ... Cited by 43 - Related articles - All 5 versions
- ►asnjournals.org M Koshikawa, M Mukoyama, K Mori, T … - Journal of the American …, 2005 - Am Soc Nephrol Podocytes play an important role in maintaining normal glomerular function and structure, and
podocyte injury leads to proteinuria and glomerulosclerosis. The family of mitogen-activated
protein kinases (MAPK; extracellular signal-regulated kinase [ERK], c-Jun N-terminal ... Cited by 42 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org K Ichinose, Y Maeshima, Y Yamamoto, H Kitayama, Y … - Diabetes, 2005 - Am Diabetes Assoc Diabetic nephropathy is one of the major microvascular complications in diabetes and is the
leading cause of end-stage renal disease worldwide. Among various factors, angiogenesis-associated
factors such as vascular endothelial growth factor (VEGF)-A and angiopoietin (Ang)-2 are ... Cited by 40 - Related articles - BL Direct - All 6 versions
MP Cohen, S Chen, FN Ziyadeh, E Shea, EA Hud, GT … - Kidney international, 2005 - nature.com Albumin modified by Amadori-glucose adducts has been linked to the development of diabetic
nephropathy through its ability, independent of hyperglycemia, to activate protein kinase C-
(PKC- ), up-regulate the transforming growth factor- (TGF- ) system, and stimulate ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org DT Wu, M Bitzer, W Ju, P Mundel, EP … - Journal of the American …, 2005 - Am Soc Nephrol Podocyte depletion occurs in most progressive glomerular diseases and is thought to result from
podocyte loss while the remaining podocytes are unable to proliferate. The underlying mechanisms
for podocyte growth arrest/differentiation and depletion remain poorly understood but may ... Cited by 34 - Related articles - BL Direct - All 5 versions
SM Marshall - Current pharmaceutical design, 2007 - ingentaconnect.com Abstract: Over the last five years, much work has underlined the important role of the podocyte
in the development of diabetic neph- ropathy. The metabolic and haemodynamic abnormalities
of the diabetic milieu act in concert, perhaps via the common effector path of oxidative ... Cited by 25 - Related articles - BL Direct - All 4 versions
V Eremina, HJ Baelde, SE Quaggin - Nephron Physiol, 2007 - content.karger.com Background/Aims: Vascular endothelial growth factor is a major regulator of angiogenesis and
vascular permeability [Carmeliet et al.: Nature 1996;380:435-439]. The podocyte, the outermost
layer of the glomerular filtration barrier, produces large amounts of VEGF-A. The ... Cited by 27 - Related articles - BL Direct - All 5 versions
