- ►diabetesjournals.org L Zheng, SJ Howell, DA Hatala, K Huang, TS … - Diabetes, 2007 - Am Diabetes Assoc It has been previously reported that aspirin inhibited the development of
diabetic retinopathy in diabetic animals, raising the possibility that
anti-inflammatory drugs may have beneficial effects on diabetic ... Cited by 42 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►nih.gov P Pacher, C Szabó - Antioxidants & redox signaling, 2005 - liebertonline.com Hyperglycemia-induced overproduction of superoxide by mitochondrial
electron-transport chain triggers several pathways of injury involved in the
pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►nih.gov IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the
pathogenesis of diabetes complications, is considered a downstream effector of
oxidative-nitrosative stress. However, some recent findings suggest that it ... Cited by 36 - Related articles - BL Direct - All 11 versions
- ►iovs.org W Chen, WJ Esselman, DB Jump, JV Busik - Investigative ophthalmology & visual science, 2005 - ARVO RESULTS. Stimulation of hRVECs with VEGF 165 , TNF , or IL-1ß for 6 to 24 hours
caused significant induction of intracellular adhesion molecule (ICAM)-1 and
vascular cell adhesion molecule (VCAM)-1 expression. Pretreatment of the ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Szabó, A Biser, R Benkő, E Böttinger, K … - Diabetes, 2006 - Am Diabetes Assoc The activation of the poly(ADP-ribose) polymerase (PARP) plays an important role
in the pathophysiology of various diseases associated with oxidative stress. We
found increased amounts of poly(ADP) ribosylated proteins in diabetic ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►nih.gov VR Drel, P Pacher, MJ Stevens, IG Obrosova - Free Radical Biology and Medicine, 2006 - Elsevier Both increased aldose reductase (AR) activity and oxidative/nitrosative stress
have been implicated in the pathogenesis of diabetic nephropathy, but the
relation between the two factors remains a subject of debate. This study ... Cited by 33 - Related articles - All 6 versions
- ►diabetesjournals.org TS Kern, CM Miller, Y Du, L Zheng, S Mohr, … - Diabetes, 2007 - Am Diabetes Assoc Pharmacologic treatment of diabetic retinopathy via eyedrops could have
advantages but has not been successful to date. We explored the effect of
topical Nepafenac, an anti-inflammatory drug known to reach the retina when ... Cited by 35 - Related articles - BL Direct - All 4 versions
TS Kern - Exp Diabetes Res, 2007 - hindawi.com Diabetes causes metabolic and physiologic abnormalities in the retina, and these
changes suggest a role for inflammation in the development of diabetic
retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, ... Cited by 34 - Related articles - View as HTML - All 12 versions
L Zheng, Y Du, C Miller, RA Gubitosi-Klug, TS … - Diabetologia, 2007 - Springer Page 1. ARTICLE Critical role of inducible nitric oxide synthase in degeneration
of retinal capillaries in mice with streptozotocin-induced diabetes ... Cited by 29 - Related articles - BL Direct - All 7 versions
