- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
CJ Groves, E Zeggini, J Minton, TM Frayling, … - Diabetes, 2006 - Am Diabetes Assoc Recent data suggest that common variation in the transcription factor 7-like 2
(TCF7L2) gene is associated with type 2 diabetes. Evaluation of such
associations in independent samples provides necessary replication and a ... Cited by 134 - Related articles - BL Direct - All 5 versions
MN Weedon, MI McCarthy, G Hitman, M Walker, … - PLoS Med, 2006 - medicine.plosjournals.org Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at
rs7903146 of TCF7L2) have been shown to predispose to type 2 diabetes mellitus
across many large studies. Risk allele frequencies ranged from 0.30 to 0.88 ... Cited by 98 - Related articles - Cached - All 15 versions
- ►nih.gov MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Conventional genetic analysis focuses on the genes that account for specific
phenotypes, while traditional epidemiology is more concerned with the
environmental causes and risk factors related to traits. Genetic ... Cited by 91 - Related articles - All 9 versions
- ►diabetesjournals.org W Winckler, MN Weedon, RR Graham, SA … - Diabetes, 2007 - Am Diabetes Assoc An important question in human genetics is the extent to which genes causing
monogenic forms of disease harbor common variants that may contribute to the
more typical form of that disease. We aimed to comprehensively evaluate the ... Cited by 56 - Related articles - BL Direct - All 5 versions
MT Malecki - Diabetes research and clinical practice, 2005 - Elsevier The clinical picture of type 2 diabetes mellitus (T2DM) is formed by impairment
in insulin secretion and resistance to insulin action. As a result of intensive
efforts of the scientists around the world mutations and polymorphisms in a ... Cited by 53 - Related articles - All 10 versions
- ►jbc.org A Miura, K Yamagata, M Kakei, H Hatakeyama … - Journal of Biological Chemistry, 2006 - ASBMB Mutations in the hepatocyte nuclear factor (HNF)-4 gene cause a form of
maturity-onset diabetes of the young (MODY1) that is characterized by impairment
of glucose-stimulated insulin secretion by pancreatic -cells. HNF-4 , a ... Cited by 51 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org MN Weedon, B Shields, G Hitman, M Walker, … - Diabetes, 2006 - Am Diabetes Assoc Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is an inhibitor
of insulin-induced activation of the insulin receptor. There is strong evidence
from several previous studies that a common coding variant of ENPP1 (K121Q) ... Cited by 48 - Related articles - BL Direct - All 5 versions
MN Weedon, KR Owen, B Shields, G Hitman, M … - Diabetes, 2005 - Am Diabetes Assoc HNF1α (TCF1) is a key transcription factor that is essential for pancreatic
β-cell development and function. Rare mutations of HNF1α cause maturity-onset
diabetes of the young. A common variant, G319S, private to the Oji-Cree ... Cited by 38 - Related articles - BL Direct - All 7 versions
LL Bonnycastle, CJ Willer, KN Conneely, AU … - Diabetes, 2006 - Am Diabetes Assoc Prior reports have suggested that variants in the genes for maturity-onset
diabetes of the young (MODY) may confer susceptibility to type 2 diabetes, but
results have been conflicting and coverage of the MODY genes has been ... Cited by 40 - Related articles - BL Direct - All 10 versions
