ND Palmer, JL Bento, JC Mychaleckyj, CD … - DIABETES-NEW YORK-, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the
dephosphorylation of pro- teins at tyrosyl residues. PTP-1B has been implicated
in negatively regulating insulin signaling by dephosphory- lating the ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►endojournals.org H Hiratani, DW Bowden, S Ikegami, S … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Our previous studies using microsatellite markers near or in the TSH receptor
(TSHR) gene revealed significant association between autoimmune thyroid disease
(AITD) in Japanese patients and TSHR microsatellite alleles. In the present ... Cited by 44 - Related articles - All 6 versions
C Phillips, J Lopez-Miranda, F Perez- … - Current Opinion in Cardiology, 2006 - journals.lww.com Purpose of review: The metabolic syndrome is a very common condition that is
associated with an increased risk of type 2 diabetes mellitus and cardiovascular
disease. The diverse clinical characteristics illustrate the complexity of ... Cited by 39 - Related articles - BL Direct - All 3 versions
- ►nih.gov MI McCarthy, E Zeggini - Current Diabetes Reports, 2006 - Springer Introduction The growing prevalence of type 2 diabetes and obesity in societies
worldwide is widely recognized as among the greatest threats to global health in
the coming century [1]. Nevertheless, we remain far from a comprehensive ... Cited by 31 - Related articles - BL Direct - All 8 versions
AM Bagwell, JL Bento, JC Mychaleckyj, BI … - Diabetes, 2005 - Am Diabetes Assoc Hepatocyte nuclear factor 4α (HNF4A), the gene for the maturity-onset diabetes
of the young type 1 monogenic form of type 2 diabetes, is within the type 2
diabetes–linked region on chromosome 20q12-q13.1 and, consequently, is a ... Cited by 32 - Related articles - All 5 versions
N Dubé, ML Tremblay - BBA-Proteins and Proteomics, 2005 - Elsevier As in other fields of biomedical research, the use of gene-targeted mice by
homologous recombination in embryonic stem cells has provided important findings
on the function of several members of the protein tyrosine phosphatase ... Cited by 30 - Related articles - All 3 versions
JC Florez, CM Agapakis, NP Burtt, M Sun, P … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates
the insulin signal transduction cascade by dephosphorylating phosphotyrosine
residues in insulin signaling molecules. Due to its chromosomal location ... Cited by 25 - Related articles - All 8 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the
pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of
multiple cytokines and hormone-like molecules from adipocytes, hepatic ... Cited by 25 - Related articles - All 3 versions
BI Freedman, DW Bowden, SS Rich, CJ Valis, … - Nephrology Dialysis Transplantation, 2005 - ERA-EDTA Results. NPL regression provided modest evidence of linkage to 13q33.3 near
D13S796 [log of the odds (LOD) = 1.72], 9q34.3 near D9S1826 (LOD = 1.22),
4p15.32 near D4S2639 (LOD = 1.11) and 1q25.1 near D1S1589 (LOD = 1.01). ... Cited by 25 - Related articles - All 6 versions
