JL Bento, ND Palmer, JC Mychaleckyj, LA Lange, CD … - Diabetes, 2004 - Am Diabetes Assoc The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), which negatively
regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin
receptor kinase activation segment. PTPN1 is located in 20q13, a genomic region linked ... Cited by 69 - Related articles - BL Direct - All 6 versions
- ►endojournals.org H Hiratani, DW Bowden, S Ikegami, S … - Journal of Clinical …, 2005 - Endocrine Soc Our previous studies using microsatellite markers near or in the TSH receptor (TSHR) gene revealed
significant association between autoimmune thyroid disease (AITD) in Japanese patients and
TSHR microsatellite alleles. In the present study, we performed a case-control analysis of ... Cited by 44 - Related articles - All 6 versions
C Phillips, J Lopez-Miranda, F Perez-Jimenez … - Current Opinion in …, 2006 - journals.lww.com Purpose of review: The metabolic syndrome is a very common condition that is associated with
an increased risk of type 2 diabetes mellitus and cardiovascular disease. The diverse clinical
characteristics illustrate the complexity of the disease, involving several dysregulated ... Cited by 39 - Related articles - BL Direct - All 3 versions
AM Bagwell, JL Bento, JC Mychaleckyj, BI Freedman, … - Diabetes, 2005 - Am Diabetes Assoc Hepatocyte nuclear factor 4α (HNF4A), the gene for the maturity-onset diabetes of the young
type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes–linked region on chromosome
20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the ... Cited by 32 - Related articles - All 5 versions
N Dubé, ML Tremblay - BBA-Proteins and Proteomics, 2005 - Elsevier As in other fields of biomedical research, the use of gene-targeted mice by homologous recombination
in embryonic stem cells has provided important findings on the function of several members of
the protein tyrosine phosphatase (PTP) family. For instance, the phenotypic ... Cited by 30 - Related articles - All 3 versions
L Tautz, M Pellecchia, T Mustelin - Expert Opin. Ther. Targets, 2006 - informahealthcare.com Protein tyrosine phosphatases (PTPs) play vital roles in numerous cellular processes and are
implicated in a growing number of human diseases, ranging from cancer to cardiovascular,
immunological, infectious, neurological and metabolic diseases. There are at least 107 ... Cited by 28 - Related articles - BL Direct - All 5 versions
JC Florez, CM Agapakis, NP Burtt, M Sun, P Almgren, L … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin
signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling
molecules. Due to its chromosomal location under a chromosome 20 linkage peak and ... Cited by 25 - Related articles - All 8 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta
cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like
molecules from adipocytes, hepatic glucose production, and likely the central nervous ... Cited by 25 - Related articles - All 3 versions
M Vinciguerra, M Foti - Archives of physiology and biochemistry, 2006 - informahealthcare.com Insulin resistance in peripheral tissues is the primary cause responsible for onset of type II diabetes
mellitus. Recently, the genetic and biochemical dissection of intracellular signalling pathways
transducing the metabolic and mitogenic effects of insulin has contributed to the ... Cited by 23 - Related articles - BL Direct - All 8 versions
