H Münzberg, MG Myers - Nature neuroscience, 2005 - cmgm.stanford.edu The increasing incidence of obesity in developed nations is an ever-growing
challenge to health care, promoting diabetes and other diseases. The hormone
leptin, which is derived from adipose tissue, regulates feeding and energy ... Cited by 178 - Related articles - All 13 versions
SH Bates, RN Kulkarni, M Seifert, MG Myers - Cell Metabolism, 2005 - Elsevier Leptin activates the long form of the leptin receptor (LRb) to control feeding
and neuroendocrine function and thus regulate adiposity. While adiposity
influences insulin sensitivity, leptin also regulates glucose homeostasis ... Cited by 42 - Related articles - All 9 versions
- ►nih.gov M Björnholm, H Münzberg, RL Leshan, EC … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The adipose-derived hormone, leptin, acts via its receptor (LRb) to convey the
status of body energy stores to the brain, decreasing feeding and potentiating
neuroendocrine energy expenditure. The failure of high levels of leptin in ... Cited by 25 - Related articles - BL Direct - All 9 versions
RL Leshan, M Björnholm, H Münzberg, MG … - Obesity, 2006 - nature.com The increasing incidence of obesity in developed nations represents an
ever-growing challenge to health care by promoting diabetes and other diseases.
The discovery of the hormone, leptin, a decade ago has facilitated the ... Cited by 24 - Related articles - All 4 versions
- ►nih.gov SP Kalra - Peptides, 2007 - Elsevier This review critically reappraises recent scientific evidence concerning central
leptin insufficiency versus leptin resistance formulations to explain metabolic
and neural disorders resulting from subnormal or defective leptin signaling ... Cited by 22 - Related articles - All 5 versions
TV Getchell, K Kwong, CP Saunders, AJ … - Physiology & behavior, 2006 - Elsevier We have investigated olfactory-mediated pre-ingestive behavior in leptin (ob/ob)
and leptin receptor (db/db) mutant mice compared to age- and gender-matched
wild-type (wt) mice. Olfactory-mediated behavior was tested using a buried ... Cited by 21 - Related articles - All 3 versions
- ►jbc.org Y Gong, R Ishida-Takahashi, EC Villanueva, … - Journal of Biological Chemistry, 2007 - ASBMB The action of leptin via the long form of its receptor (LepRb) is central to the
control of body energy homeostasis and neuroendocrine function, but the
mechanisms by which LepRb regulates intracellular signaling have remained ... Cited by 20 - Related articles - All 6 versions
- ►jneurosci.org H Munzberg, EE Jobst, SH Bates, J Jones, E … - Journal of Neuroscience, 2007 - Soc Neuroscience Leptin directly suppresses the activity of orexigenic neurons in the
hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity
(CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the ... Cited by 15 - Related articles - All 5 versions
- ►nih.gov AA Steiner, AA Romanovsky - Progress in lipid research, 2007 - Elsevier In addition to playing a central role in energy homeostasis, leptin is also an
important player in the inflammatory response. Systemic inflammation is
accompanied by fever (less severe cases) or hypothermia (more severe ... Cited by 12 - Related articles - All 3 versions
- ►nih.gov A Abizaid, TL Horvath - Regulatory peptides, 2008 - Elsevier Recent years have seen an impetus in the study for central mechanisms regulating
energy balance, and caloric intake possibly as a response to the obesity
pandemic. This renewed interest as well as drastic improvements in the ... Cited by 12 - Related articles - All 3 versions
