- ►physiology.org N Wettschureck, S Offermanns - Physiological reviews, 2005 - Am Physiological Soc Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge variety
of receptors to channel proteins, enzymes, and other effector molecules. Multiple subforms of
G proteins together with receptors, effectors, and various regulatory proteins represent the ... Cited by 171 - Related articles - BL Direct - All 5 versions
- ►cardiovascres.org BN Finck - Cardiovascular research, 2007 - cardiovascres.org Myocardial energy metabolism is an important determinant of cardiac structure and function.
Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac
disease. The peroxisome proliferator-activated receptor family (PPAR , β/ , ) of nuclear ... Cited by 36 - Related articles - All 8 versions
N Keshava, JC Caldwell - Environmental health perspectives, 2006 - pubmedcentral.nih.gov Peroxisome proliferator–activated receptor α (PPARα) is thought to be involved in several different
diseases, toxic responses, and receptor pathways. The US Environmental Protection Agency
2001 draft trichloroethylene (TCE) risk assessment concluded that although PPAR may ... Cited by 17 - Related articles - BL Direct - All 15 versions
- ►physiology.org J Huang, H Zhou, S Mahavadi, W Sriwai, … - American Journal of …, 2007 - Am Physiological Soc In smooth muscle of the gut, G q -coupled receptor agonists activate preferentially PLC- 1 to stimulate
phosphoinositide (PI) hydrolysis and inositol 1,4,5-trisphosphate (IP 3 ) generation and induce
IP 3 -dependent Ca 2+ release. Inhibition of Ca 2+ mobilization by cAMP- (PKA) and ... Cited by 13 - Related articles - BL Direct - All 5 versions
J Kim, JR Keys, AD Eckhart - Cellular signalling, 2006 - Elsevier Many G protein-coupled receptors can couple to multiple G proteins to convey their intracellular
signaling cascades. The receptors for lysophosphatidic acid (LPA) possess this ability. LPA receptors
are important mediators of a wide variety of biological actions including cell migration, ... Cited by 10 - Related articles - All 4 versions
X Yu, YA Tesiram, RA Towner, A Abbott, E … - Cardiovascular …, 2007 - biomedcentral.com After 4 weeks of hyperglycemia one marker of mitochondrial function, NADH oxidase activity,
was decreased to 50% of control animals. MRI studies of diabetic mice at 4 weeks demonstrated
significant deficits in myocardial morphology and functionality including: a decreased left ... Cited by 9 - Related articles - Cached - All 10 versions
- ►ahajournals.org T Tokudome, I Kishimoto, T Horio, Y Arai, DO … - Circulation, 2008 - Am Heart Assoc Methods and Results— In cultured cardiac myocytes, treatment of atrial natriuretic peptide stimulated
the binding of guanosine 3',5'-cyclic monophosphate-dependent protein kinase (PKG) I- to
RGS4, PKG-dependent phosphorylation of RGS4, and association of RGS4 and G q . In ... Cited by 9 - Related articles - All 8 versions
- ►physiology.org Y Fu, X Huang, L Piao, AN Lopatin, RR … - American Journal of …, 2007 - Am Physiological Soc G protein-coupled receptors play a pivotal role in regulating cardiac automaticity. Their function
is controlled by regulator of G protein signaling (RGS) proteins acting as GTPase-activating proteins
for G subunits to suppress G i and G q signaling. Using knock-in mice in which G i2 -RGS ... Cited by 6 - Related articles - BL Direct - All 5 versions
BN Finck - Expert review of cardiovascular therapy, 2006 - ingentaconnect.com Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus and is the
most common cause of death. With the emerging pandemic of obesity and resulting metabolic
abnormalities, the occurrence of cardiovascular disease is almost nearly certain to ... Cited by 4 - Related articles - All 5 versions
