- ►aspetjournals.org AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET Islet transplantation may be used to treat type I diabetes. Despite tremendous
progress in islet isolation, culture, and preservation, the clinical use of this
modality of treatment is limited due to post-transplantation challenges to ... Cited by 32 - Related articles - BL Direct - All 13 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N … - Endocrine Reviews, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro
discovery in 1984, evolving via descriptive and phenomenological studies to
detailed mapping of the signalling pathways, gene- and protein expression ... Cited by 20 - Related articles - BL Direct - All 6 versions
M Freemark - Horm Res, 2006 - content.karger.com The metabolic adaptations of pregnancy are designed to support the demands of
fetal and neonatal development and growth. In early and mid-gestation, maternal
metabolism is directed towards energy storage and utero-placental ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Jackerott, A Moldrup, P Thams, ED … - Diabetes, 2006 - Am Diabetes Assoc Pancreatic ß-cell growth and survival and insulin production are stimulated by
growth hormone and prolactin through activation of the transcription factor
signal transducer and activator of transcription (STAT)5. To assess the ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►shouxi.net Y Fujinaka, K Takane, H Yamashita, RC … - Journal of Biological Chemistry, 2007 - ASBMB One of the goals in the treatment for diabetes is to enhance pancreatic beta
cell function, proliferation, and survival. This study explores the role of
lactogenic hormones, prolactin (PRL) and placental lactogen (PL), in beta ... Cited by 14 - Related articles - All 4 versions
- ►endojournals.org JL Beith, EU Alejandro, JD Johnson - Endocrinology, 2008 - Endocrine Soc A relative decrease in β-cell mass is key in the pathogenesis of type 1
diabetes, type 2 diabetes, and in the failure of transplanted islet grafts. It
is now clear that β-cell duplication plays a dominant role in the ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21,
p27) are critical for normal regulation of β-cell proliferation, mass, and
function. The retinoblastoma protein, pRb, is positioned at the very end of ... Cited by 12 - Related articles - BL Direct - All 5 versions
KJ Chang-Chen, R Mullur, E Bernal-Mizrachi - Reviews in Endocrine & Metabolic Disorders, 2008 - Springer Abstract Type 2 diabetes mellitus is a complex disease characterized by b-cell
failure in the setting of insulin resistance. In early stages of the disease,
pancreatic b-cells adapt to insulin resistance by increasing mass and ... Cited by 11 - Related articles - All 2 versions
RC Vasavada, L Wang, Y Fujinaka, KK Takane, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Diabetes results from a deficiency of functional β-cells. Previous
studies have identified hepatocyte growth factor (HGF) and parathyroid
hormone–related protein (PTHrP) as two potent β-cell mitogens. The ... Cited by 7 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org G Cohen, D Ilic, J Raupachova, WH Horl - The Journal of Immunology, 2008 - Am Assoc Immnol The serum levels of resistin, a 12-kDa protein primarily expressed in
inflammatory cells in humans, are increased in patients with chronic kidney
disease and in those with diabetes mellitus. Both groups of patients have ... Cited by 7 - Related articles - All 2 versions
