- ►pnas.org T Okada, CW Liew, J Hu, C Hinault, MD … - Proceedings of the …, 2007 - National Acad Sciences Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation
in most mammalian tissues including pancreatic islets. To explore the specificity of insulin receptors
in compensatory β-cell growth, we examined two models of insulin resistance. In the first ... Cited by 46 - Related articles - BL Direct - All 9 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by an organism to
maintain glucose homeostasis. Defects in development, maintenance, or expansion of ß-cell
mass can result in impaired glucose metabolism and diabetes. Thus, identifying the ... Cited by 37 - Related articles - All 4 versions
RN Kulkarni - Reviews in Endocrine & Metabolic Disorders, 2005 - Springer Page 1. Reviews in Endocrine & Metabolic Disorders 2005;6:199–210 C 2005 Springer
Science + Business Media, Inc. Manufactured in The Netherlands. New Insights into the Roles
of Insulin/IGF-I in the Development and Maintenance of β-Cell Mass ... Cited by 36 - Related articles - BL Direct - All 3 versions
RK Gupta, N Gao, RK Gorski, P White, OT … - Genes & …, 2007 - genesdev.cshlp.org The failure to expand functional pancreatic β-cell mass in response to increased metabolic demand
is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing
β-cells is the principle mechanism for β-cell expansion in adult mice. Here we ... Cited by 36 - Related articles - BL Direct - All 8 versions
- ►aspetjournals.org AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in islet
isolation, culture, and preservation, the clinical use of this modality of treatment is limited due
to post-transplantation challenges to the islets such as the failure to revascularize and ... Cited by 32 - Related articles - BL Direct - All 13 versions
J Kajstura, R Bolli, EH Sonnenblick, P Anversa, A … - Journal of molecular and …, 2006 - Elsevier Three decades after its recognition, apoptosis remains an appealing topic of research. Thousands
of articles and commentaries concerning the various aspects of this multifaceted phenomenon
have been published and it may be challenging to write a comprehensive review about ... Cited by 22 - Related articles - All 5 versions
VA Ezzat, ER Duncan, SB Wheatcroft, MT … - Diabetes, obesity & …, 2008 - pt.wkhealth.com Patients with insulin resistance and type 2 diabetes have an excessive risk of cardiovascular
disease (CVD); this increased risk is not fully explained by traditional risk factors such as hypertension
and dyslipidaemias. There is now compelling evidence to suggest that abnormalities of ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org DA Taylor-Fishwick, A Bowman, N Hamblet, … - Journal of …, 2006 - Soc Endocrinology Islet neogenesis associated protein (INGAP) is a protein factor that can stimulate new islet mass
from adult pancreatic progenitor cells. In models of islet neogenesis, INGAP expression is elevated
in pancreatic acinar cells. Using a transgenic model to drive a sustained expression of ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►physiology.org K Robertson, Y Lu, K De Jesus, B Li, Q Su, … - American Journal of …, 2008 - Am Physiological Soc Insulin-like growth factor I (IGF-I) is normally produced from hepatocytes and various other cells
and tissues, including the pancreas, and is known to stimulate islet cell replication in vitro, prevent
Fas-mediated β-cell destruction and delay the onset of diabetes in nonobese diabetic ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►endojournals.org AV Loladze, MA Stull, AM Rowzee, J DeMarco, JH … - Endocrinology, 2006 - Endocrine Soc Postnatal development of the mammary gland requires interactions between the epithelial and
stromal compartments, which regulate actions of hormones and growth factors. IGF-I is expressed
in both epithelial and stromal compartments during postnatal development of the ... Cited by 11 - Related articles - BL Direct - All 5 versions
